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OP0290 : EMAPALUMAB (ANTI-INTERFERON-GAMMA MONOCLONAL ANTIBODY) IN PATIENTS WITH MACROPHAGE ACTIVATION SYNDROME (MAS) COMPLICATING SYSTEMIC JUVENILE IDIOPATHIC ARTHRITIS (SJIA)

Researchers

Presenter

  • F. De Benedetti

Principal Investigators

  • P. Brogan

  • C. Bracaglia

  • M. Pardeo

  • G. Marucci

  • E. Sacco

  • D. Eleftheriou

  • C. Papadopoulou

  • A. Grom

  • P. Quartier

  • R. Schneider

  • P. Jacqmin

  • R. Frederiksen

  • M. Ballabio

  • C. De Min

Medical Centers

  • UCL Institute of Child Health, and Great Ormond Street Hospital NHS Foundation Trust, Infection, Immunology, and Rheumatology section,, london, United Kingdom

  • Cincinnati Children’s Hospital, Division of Rheumatology, Cincinnati, United States of America

  • Paris-Descartes University, IMAGINE Institute, RAISE Reference Centre, Pediatric Immuno-Hematology and Rheumatology Unit, Necker Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France

  • The Hospital for Sick Children, Department of Pediatrics, Division of Rheumatology, Toronto, Canada

  • MnS Modelling and Simulation, Dinant, Belgium

  • Swedish Orphan Biovitrum (Sobi) AG, Basel, Switzerland

Locations

  • Italy

  • United Kingdom

  • United States

  • France

  • Canada

  • Belgium

  • Switzerland

Companies

  • N/A

Study Components

Therapeutic Area

  • Musculoskeletal

  • Autoimmune (AI)

Disease

  • Macrophage activation syndrome

  • Rheumatoid arthritis

  • Inflammatory Arthritis

Biomarkers

  • Alanine transaminase

  • Aspartate aminotransferase

  • Lactate dehydrogenase

  • Albumin/creatinine

Drug/Treatment

  • Interferon Gamma

  • Glucocorticoid

  • NI0501

  • Fibrinogen (IV)

  • Interferon

Outcome

  • N/A

Study Design

  • Open Label

  • Single Arm

Phase

  • NA

Study Id's

  • NCT03311854

Sponsors

  • Abbvie

Result

  • N/A

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