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OP0054 : EFFICACY OF GUSELKUMAB, A MONOCLONAL ANTIBODY THAT SPECIFICALLY BINDS TO THE P19-SUBUNIT OF IL-23, ON ENDPOINTS RELATED TO AXIAL INVOLVEMENT IN PATIENTS WITH ACTIVE PSA WITH IMAGING-CONFIRMED SACROILIITIS: WEEK-24 RESULTS FROM TWO PHASE 3, RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED STUDIES

Researchers

Presenter

  • P. Helliwell

Principal Investigators

  • D. D. Gladman

  • D. Poddubnyy

  • P. J. Mease

  • X. Baraliakos

  • A. Kollmeier

  • E. C. Hsia

  • X. L. Xu

  • S. Sheng

  • P. Agarwal

  • B. Zhou

  • S. D. Chakravarty

  • M. Shawi

  • C. Karyekar

  • A. Deodhar

  • D. Van der Heijde

Medical Centers

  • University of Leeds, Leeds, United Kingdom

  • Toronto Western Hospital and University of Toronto, Ontario, Canada

  • Charite-Universitaetsmedizin Berlin, Campus Benjamin Franklin, Berlin, Germany

  • German Rheumatism Research Centre, Berlin, Germany

  • Swedish Medical Center/Providence St Joseph Health, and University of Washington, Seattle, WA

  • Rheumazentrum Ruhrgebiet, Ruhr-University Bochum, Herne, Germany

  • Janssen Research & Development, Raritan, United States of America

  • Perelman School of Medicine, Philadelphia, United States of America

  • Janssen Scientific Affairs, LLC, Raritan, United States of America

  • Temple University School of Medicine, Philadelphia, Pennsylvania, United States

  • , Janssen Global Services, LLC, Horsham, PA, United States of America

  • Oregon Health & Science University, Portland, United States of America

  • Leiden University Medical Centre, Leiden, Netherlands

Locations

  • United Kingdom

  • Canada

  • Germany

  • United States

  • Netherlands

Companies

  • N/A

Study Components

Therapeutic Area

  • Musculoskeletal

Disease

  • Sacroiliitis

Biomarkers

  • Prostate specific antigen

  • Interleukin-23

Drug/Treatment

  • guselkumab (IV)

Outcome

  • N/A

Study Design

  • Randomized

  • Placebo Control

  • Double Blind/Blinded

  • Controlled

Phase

  • III

Study Id's

  • N/A

Sponsors

  • Abbvie

Result

  • N/A

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