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THU0028 : AN EXPLANTION FOR HOW VIRAL INFECTION MAY TRIGGER SPONDYLOARTHROPATHY BASED ON TLR9 DRIVEN TNF RESPONSES FROM ENTHESEAL DERIVED PLASMACYTOID DENDRITIC CELLS

Researchers

Presenter

  • Q. Zhou

Principal Investigators

  • J. Vadakekolathu

  • K. Sharif

  • T. Russell

  • H. Rowe

  • P. Millner

  • P. Loughenbury

  • A. S. Rao

  • R. Dunsmuir

  • C. Bridgewood

  • Y. El-Sherbiny

  • D. Mcgonagle

Medical Centers

  • Sichuan Provincial People’s Hospital, Department of Rheumatology and Immunology, Chengdu, China

  • University of Leeds, Leeds Institue of Rheumatic and Musculoskeletal Medicine, Leeds, United Kingdom

  • Nottingham Trent University, Department of Biosciences, Nottingham, United Kingdom

  • Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom

  • Leeds Teaching Hospitals, National Institute for Health Research (NIHR) Leeds Biomedical Research Centre, Leeds, United Kingdom

Locations

  • China

  • United Kingdom

Companies

  • N/A

Study Components

Therapeutic Area

  • Musculoskeletal

  • Genetic Disorder

  • Autoimmune (AI)

Disease

  • Spondyloarthritis

  • Immunodeficiency, common variable, 10

Biomarkers

  • Tumor necrosis factor

Drug/Treatment

  • N/A

Outcome

  • N/A

Study Design

  • N/A

Phase

  • NA

Study Id's

  • N/A

Sponsors

  • Novartis

Result

  • N/A

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