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: Reduced Intensity Conditioned Bone Marrow Transplant with Post-Transplant Cyclophosphamide and Donor-Derived Mesenchymal Stromal Cell Infusions for Recessive Dystrophic Epidermolysis Bullosa

Researchers

Presenter

  • Christen L. Ebens

Principal Investigators

  • John A McGrath

  • Katsuto Tamai

  • Hovnanian Alain

  • John E. Wagner

  • Megan Riddle

  • Douglas R Keene

  • Todd E. DeFor

  • Rebecca Tryon

  • Mei Chen

  • David T Woodley

  • Kristin Hook

  • Jakub L Tolar

Medical Centers

  • Department of Pediatric Blood and Marrow Transplant, University of Minnesota, Minneapolis, MN

  • St Johns Institute of Dermatology, Kings College London, London, United Kingdom

  • Department of Stem Cell Therapy Science, Graduate School of Medicine, University of Osaka, Osaka, Japan

  • INSERM UMR1163, Imagine Institute, Department of Genetics, University Paris Descartes, Necker Hospital, Paris, France

  • Department of Pediatric Blood and Marrow Transplant, University of Minnesota, Minneapolis, MN

  • Microimaging Center, Shriners Hospital for Children, Portland, OR

  • Biostatistics and Bioinformatics Core, Masonic Cancer Center, University of Minnesota, Minneapolis, MN

  • Genetics Division, Department of Medicine, University of Minnesota, Minneapolis, MN

  • Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA

  • Department of Pediatrics, University of Minnesota, Minneapolis, MN

Locations

  • United States

  • United Kingdom

  • Japan

  • France

Companies

  • N/A

Study Components

Therapeutic Area

  • Dermatology

  • Genetic Disorder

  • Autoimmune (AI)

Disease

  • Graft-versus-host disease

  • Epidermolysis bullosa

  • Epidermolysis bullosa dystrophica, autosomal recessive

Biomarkers

  • Mesenchymal stem cells

Drug/Treatment

  • Methylprednisolone

  • Cyclophosphamide

  • Cyclophosphamide Injection

  • fludarabine tablet

  • Tacrolimus

Outcome

  • N/A

Study Design

  • N/A

Phase

  • NA

Study Id's

  • N/A

Sponsors

  • N/A

Result

  • N/A

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