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: Cyclophosphamide Exerts Significant Immunomodulatory Function in Myeloma Patients Treated with Pomalidomide and Dexamethasone

Researchers

Presenter

  • James Croft

Principal Investigators

  • Andrew Hall

  • Katrina Walker

  • Amy L Sherborne

  • Kevin Boyd

  • Mamta Garg

  • Charlotte Pawlyn

  • Debbie Sherratt

  • Sadie Reed

  • William E Pierceall

  • Gordon Cook

  • Anjan Thakurta

  • Sarah R Brown

  • Martin Kaiser

Medical Centers

  • Royal Marsden Hospital and Institute of Cancer Research, London, United Kingdom

  • The Royal Marsden Hospital, London, United Kingdom

  • Clinical Trials Research Unit, Leeds Institute of Clinical Trials Research, University of Leeds, Leeds, United Kingdom

  • Leicester Royal Infirmary Haematology, Leicester, United Kingdom

  • Translational Development and Diagnostics, Celgene Corporation, Summit, NJ

  • Leeds Institute of Cancer and Pathology, University of Leeds, Leeds, United Kingdom

  • Celgene Corporation, Summit, NJ

Locations

  • United Kingdom

  • United States

Companies

  • Celgene Corporation

Study Components

Therapeutic Area

  • Oncology (ONC)

Disease

  • Multiple Myeloma

Biomarkers

  • Cluster of Differentiation 2AP

  • Cluster of Differentiation 4

  • Proliferation marker protein Ki-67

  • Cluster of differentiation 8A

  • Protein Tyrosine Phosphatase, Receptor Type C

  • Human Leukocyte Antigen – DR isotype

  • L-selectin

Drug/Treatment

  • Cyclophosphamide

  • Cyclophosphamide Injection

  • Dexamethasone

  • Dekpak 13 Day Taperpak

  • Pomalidomide

  • CC-4047

Outcome

  • N/A

Study Design

  • Randomized

  • Pharmacodynamics

Phase

  • II

Study Id's

  • N/A

Sponsors

  • N/A

Result

  • N/A

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