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: Results of a Phase 2 Trial of the Monocyte-Targeted Histone Deacetylase Inhibitor Tefinostat (CHR-2845) in Chronic Myelomonocytic Leukemia (CMML) — the UK Monocle Study

Researchers

Presenter

  • Steven Knapper

Principal Investigators

  • Michael Dennis

  • Mark W Drummond

  • Robert K. Hills

  • Richard James Dillon

  • Christopher Pocock

  • Dominic J. Culligan

  • Paresh Vyas

  • Daniel Wiseman

  • Joanna Zabkiewicz

  • Marie Hodges

  • Catherine Cargo

  • Jan Taylor

  • Laura Upton

  • Melissa Wright

  • David Bowen

Medical Centers

  • Department of Haematology, Cardiff University, School of Medicine, Cardiff, United Kingdom

  • Department of Haematology and Transplant, The Christie, Manchester, United Kingdom

  • Beatson West of Scotland Cancer Centre and University of Glasgow, Glasgow, United Kingdom

  • Centre for Trials Research, College of Biomedical & Life Sciences, Cardiff University, Cardiff, United Kingdom

  • Kings College London, London, United Kingdom

  • East Kent Hospitals, Canterbury, United Kingdom

  • Aberdeen Royal Infirmary, Aberdeen, United Kingdom

  • IGF Group, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, United Kingdom

  • Institute of Cancer & Genetics, Cardiff University, Cardiff, Wales, United Kingdom

  • St James's University Hospital, Haematological Malignancy Diagnostic Service (HMDS), Leeds, United Kingdom

  • Centre for Trials Research, College of Biomedical & Life Sciences, Cardiff University, Cardiff, United Kingdom

  • Department of Histopathology, Leeds Teaching Hospitals NHS Foundation Trust, Leeds, United Kingdom

Locations

  • United Kingdom

Companies

  • N/A

Study Components

Therapeutic Area

  • Oncology (ONC)

Disease

  • Chronic myelomonocytic leukemia

Biomarkers

  • Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Epsilon

Drug/Treatment

  • Hydroxycarbamide

  • Tefinostat

Outcome

  • N/A

Study Design

  • Single Arm

  • Multinational

Phase

  • II

Study Id's

  • N/A

Sponsors

  • N/A

Result

  • N/A

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