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: Oral Vitamin C Supplementation to Azacitidine in Patients with Myeloid Cancer: Normalization of Plasma Vitamin C Induces Epigenetic Changes

Researchers

Presenter

  • Linn Gillberg

Principal Investigators

  • Andreas Due rskov

  • Ammar Nasif

  • Hitoshi Otani

  • Zachary Madaj

  • Jakob Werner Hansen

  • Johanne Bay Mogensen

  • Minmin Liu

  • Inge Hgh Dufva

  • Lykkesfeldt Jens

  • Petra Hajkova

  • Peter A. Jones

  • Kirsten Grnbk

Medical Centers

  • Department of Oncology 5073 Rigshospitalet Copenhagen University Hospital, Copenhagen, Denmark

  • Biotech Research and Innovation Centre (BRIC), University of Copenhagen, Copenhagen, Denmark

  • Biotech Research and Innovation Centre (BRIC), University of Copenhagen, Copenhagen, Denmark

  • MRC London Institute of Medical Sciences, Imperial College, London, United Kingdom

  • Center for Epigenetics, Van Andel Research Institute, Grand Rapids, MI

  • Bioinformatics & Biostatistics Core, Van Andel Research Institute, Grand Rapids, MI

  • Dept. of Haematology, Herlev Hospital, Copenhagen University Hospital, Herlev, Denmark

  • Department of Veterinary and Animal Sciences, University of Copenhagen, Frederiksberg, Denmark

Locations

  • Denmark

  • United Kingdom

  • United States

Companies

  • N/A

Study Components

Therapeutic Area

  • Oncology (ONC)

Disease

  • Chronic myelomonocytic leukemia

  • Alpha-thalassemia myelodysplasia syndrome

  • Acute myelocytic leukemia

  • Solid malignancies

Biomarkers

  • Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Epsilon

Drug/Treatment

  • 5-Azacytidine

  • Vidaza

Outcome

  • N/A

Study Design

  • Randomized

  • Placebo Control

  • Controlled

Phase

  • NA

Study Id's

  • N/A

Sponsors

  • N/A

Result

  • N/A

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