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: The Malignant Hemopoietic Clone of Triple Negative Patients with Myelofibrosis Shows in Vitro Functional Defects but Is Highly Responsive to the Pro-Survival Signals of Circulating Autologous Microvesicles

Researchers

Presenter

  • Lucia Catani

Principal Investigators

  • Dorian Forte

  • Martina Barone

  • Cristina Morsiani

  • Francesco Fabbri

  • Giorgia Simonetti

  • Francesca Ricci

  • Samantha Bruno

  • Natalia Calonghi

  • Emanuela Ottaviani

  • Marco Romano

  • Pierluigi Tazzari

  • Claudio Franceschi

  • Massimiliano Bonaf

  • Nicola Vianelli

  • Giovanni Martinelli

  • Michele Cavo

  • Miriam Capri

  • Giuseppe Auteri

  • Francesca Palandri

Medical Centers

  • "Seragnoli" Institute of Hematology, Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy

  • Wellcome Trust-Medical Research Council Cambridge Stem Cell Institute and Department of Haematology,University of Cambridge,Bologna,United Kingdom

  • Department of Medical Oncology, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS, Meldola, Italy

  • DIMES - Department of Experimental, Diagnostic and Specialty Medicine, Institute of Hematology, University of Bologna, Bologna, Italy

  • Immunohematology and Blood Bank Service,Azienda Ospedaliero-Universitaria S. Orsola-Malpighi,Bologna,Italy

  • DIMES - Department of Experimental, Diagnostic and Specialty Medicine, Institute of Hematology, University of Bologna, Bologna, Italy

  • Department of Pharmacy and Biotechnology, University of Bologna, Italy

  • School of Immunology & Microbial Sciences, King's College London, London, United Kingdom

  • Institute of Hematology “L. and A. Seràgnoli”, Sant’Orsola-Malpighi University Hospital,Bologna,Italy

  • Institute of Hematology "L. and A. Seràgnoli", Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, "S. Orsola-Malpighi" Hospital, Bologna, Italy

Locations

  • Italy

  • United Kingdom

Companies

  • N/A

Study Components

Therapeutic Area

  • Oncology (ONC)

Disease

  • Myelofibrosis

Biomarkers

  • Cluster of Differentiation 34

  • P-selectin

  • Granulin precursor

  • Integrin subunit beta 3

  • Interleukin 1 beta

  • Interleukin 6

Drug/Treatment

  • CXCL12

Outcome

  • N/A

Study Design

  • N/A

Phase

  • NA

Study Id's

  • N/A

Sponsors

  • N/A

Result

  • N/A

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