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: Bone Marrow Stromal Cells Mediate Adhesion Based Drug Resistance in Acute Myeloid Leukaemia through Reciprocal Feedback of the β-Catenin/CD44 Signalling Axis

Researchers

Presenter

  • Lihui Zhuang

Principal Investigators

  • Richard Darley

  • Oliver G. Ottmann

  • Joanna Zabkiewicz

  • Caroline Alvares

Medical Centers

  • Department of Haematology, Cardiff University, School of Medicine, Cardiff, United Kingdom

Locations

  • United Kingdom

Companies

  • N/A

Study Components

Therapeutic Area

  • Oncology (ONC)

Disease

  • Acute myelocytic leukemia

Biomarkers

  • Mitogen-activated protein kinase

  • C-C Motif Chemokine Ligand 3

  • C-C Motif Chemokine Ligand 4

  • Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

  • Cluster of Differentiation 44

  • Complement Component 5a

  • Extracellular signal-regulated kinase

  • Galectin-3

  • Interleukin-2

  • SRY-Box 2

  • TIMP Metallopeptidase Inhibitor 1

  • PI3K/AKT

  • MAPK/ERK

Drug/Treatment

  • N/A

Outcome

  • N/A

Study Design

  • N/A

Phase

  • NA

Study Id's

  • N/A

Sponsors

  • N/A

Result

  • N/A

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