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: NOX2 Derived Superoxide Induces Pro-Tumoral p16INK4a Driven Senescence in the AML Bone Marrow Microenvironment

Researchers

Presenter

  • Charlotte Hellmich

Principal Investigators

  • Amina Abdul-Aziz

  • Yu Sun

  • Christopher Richard Marlein

  • Eoghan Forde

  • Rachel E Piddock

  • Manar Shafat

  • Adam Morfakis

  • Mehta Tarang

  • Federica Di Palma

  • Christopher Ingham

  • Angela Collins

  • Anna Haestier

  • Judith Campisi

  • Kristian Bowles

  • Stuart Rushworth

Medical Centers

  • Norfolk and Norwich University Hospitals NHS Trust, Norwich, United Kingdom.

  • Medicine, Norwich Medical School University of East Anglia, Norwich, United Kingdom

  • Medicine, University of East Anglia, Norwich Medical School, Norwich, United Kingdom

  • Quadram Institute, UK, Coventry, United Kingdom

  • Paediatrics, Norfolk and Norwich University Hospitals NHS Foundation Trust,Norwich, United Kingdom

  • Paediatrics, Norfolk and Norwich University Hospitals NHS Foundation Trust,Norwich, United Kingdom

  • Buck Inst. for Research on Aging, Novato, CA.

Locations

  • United Kingdom

Companies

  • N/A

Study Components

Therapeutic Area

  • N/A

Disease

  • N/A

Biomarkers

  • Cluster of Differentiation 105 Antigen

  • Cluster of Differentiation 31

  • Cluster of Differentiation 34

  • Cluster of differentiation 45

  • Interleukin 6

  • Thioredoxin

Drug/Treatment

  • Sulfasalazine

Outcome

  • N/A

Study Design

  • N/A

Phase

  • NA

Study Id's

  • N/A

Sponsors

  • N/A

Result

  • N/A

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