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: Metformintreatment Overcomes ATRA-Resistance in Acute Promyelocytic Leukemia and Increases FOXO3A Expression

Researchers

Presenter

  • Diego Antonio Pereira-Martins

Principal Investigators

  • Pedro Luis Franca-Neto

  • Isabel Weinhuser

  • Josiane Lilian Schiavinato

  • Patrcia Vianna Bonini Palma

  • Camila Bonaldo

  • Luisa C A Koury

  • Mariane Cristina Do Nascimento

  • Raul Antnio Morais Melo

  • Rosane Bittencourt

  • Katia B B Pagnano

  • Ricardo Pasquini

  • Evandro Maranhao Fagundes

  • Ana Beatriz F. Gloria

  • Fabio R. Kerbauy

  • Maria de Lourdes Chauffaille

  • Armand Keating

  • Martin S. Tallman

  • Raul Ribeiro

  • Richard Dillon

  • Arnold Ganser

  • Bob Lowenberg

  • Peter Valk

  • Francesco Lo-Coco

  • Miguel A. Sanz

  • Nancy Berliner

  • Antonio R. Lucena-Araujo

  • Eduardo Magalhaes Rego

Medical Centers

  • Medical School of Ribeirao Preto and Center for Cell Based Therapy, University of São Paulo, Ribeirão Preto, Brazil

  • Medical School of Ribeirao Preto and Center for Cell Based Therapy, University of São Paulo, Ribeirão Preto, Brazil

  • Department of Genetics, Federal University of Pernambuco., Recife, Brazil

  • Center for Cell Based Therapy, University of Sao Paulo, Ribeirao Preto, Brazil

  • Division of Hematology, Department of Internal Medicine, Medical School of Ribeirão Preto, University of São Paulo, Ribeirão Preto, Brazil

  • Center for Cell-based Therapy, Regional Hemotherapy Center of the School of Medicine of Ribeirão Preto, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, Sao Paulo, Brazil

  • Center for Cell Based Therapy, University of Sao Paulo, Ribeirao Preto, Brazil

  • Medical School of Ribeirao Preto, USP, Ribeirao Preto, Brazil

  • Center for Cell Based Therapy, Ribeirão Preto Medical School, São Paulo University, Ribeirão Preto, Brazil

  • Department of Internal Medicine, University of Pernambuco and Fundação HEMOPE, Recife, Brazil

  • , University Hospital of the Federal University of Rio Grande do Sul,Porto Alegre,Brasil

  • Division of Hematology, Department of Medicine, Hemocentro, University of Campinas, Campinas, Brazil

  • INCT do Sangue, Hemocentro UNICAMP,University of Campinas, Sao Paulo, Brazil

  • Hematology Division, Federal University of Paraná, Curitiba, Brazil

  • Hematology Division, Federal University of Minas Gerais, Belo Horizonte, Brazil

  • Federal University of Sao Paulo, Sao Paulo, UT

  • Federal University of Sao Paulo (UNIFESP), Sao Paulo, Brazil

  • Hematologia e Hemoterapia, Universidade Federal de Sao Paulo, Sao Paulo, Brazil

  • Princess Margaret Cancer Centre, Princess Margaret Hospital, Toronto, ON, Canada

  • Lymphoma Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY

  • Department of Oncology and Global Medicine, International Outreach Program, St. Jude Children's Research Hospital, Memphis, TN

  • Kings College London, London, United Kingdom

  • Dept. Hematology, Hemostaseology, Oncology & Stem Cell Transplantation, Hannover Medical School, Hannover, Germany

  • Department of Medical Oncology, VU University Medical Center, Amsterdam, Netherlands

  • Editor-in-Chief, Blood, Washington, DC

  • Department of Biomedicine and Prevention, University Tor Vergata, Rome, Italy

  • University of Rome Tor Vergata, Rome, Italy

  • Department of Medicine, Hospital Universitari i Politecnic La Fe and Centro de Investigación Biomédica en Red de Cáncer, University of Valencia and Instituto Carlos III, Madrid, Madrid, Spain

  • CIBERDEM, Madrid, Spain

  • Department of Medicine, Brigham and Women's Hospital, Boston, MA

  • Medical School of Ribeirao Preto, USP, Ribeirao Preto, Brazil

  • Center for Cell-Based Therapy, Medical School of Ribeirão Preto, University of São Paulo, Ribeirão Preto, São Paulo, Brazil

  • Ribeirao Preto Medical School, University of Sao Paulo, Sao Paulo, Brazil

Locations

  • Brazil

  • Canada

  • United States

  • United Kingdom

  • Germany

  • Netherlands

  • Italy

  • Spain

Companies

  • N/A

Study Components

Therapeutic Area

  • Oncology (ONC)

Disease

  • Acute promyelocytic leukemia

Biomarkers

  • Promyelocytic Leukemia

Drug/Treatment

  • Metformin Hydrochloride

  • Tretinoin

Outcome

  • N/A

Study Design

  • Cohort

Phase

  • NA

Study Id's

  • N/A

Sponsors

  • N/A

Result

  • N/A

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