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: Methotrexate-Associated Toxicity in Children with Down Syndrome and Acute Lymphoblastic Leukemia during Consolidation Therapy with High Dose Methotrexate According to ALL-BFM Treatment Regimen

Researchers

Presenter

  • Mirko Kroll

Principal Investigators

  • Kirsten Bleckmann

  • Anja Mricke

  • Denis Martin Schewe

  • Martin Stanulla

  • Martin Zimmermann

  • Martin Schrappe

  • Gunnar Cario

Medical Centers

  • Department of General Pediatrics, University Hospital Schleswig-Holstein, Kiel, Germany

  • Dept. of Pediatrics, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany

  • Pediatric Hematology and Oncology, Hannover Medical School, Hannover, Germany

Locations

  • Germany

Companies

  • N/A

Study Components

Therapeutic Area

  • Oncology (ONC)

  • Blood/haematological Diseases

  • Genetic Disorder

Disease

  • Acute lymphoblastic leukemia

  • Thrombocytopenia

  • Down syndrome

Biomarkers

  • Circulating tumor cells

  • Ubiquitin A-52 Residue Ribosomal Protein Fusion Product 1

Drug/Treatment

  • 6-mercaptopurine

  • Methotrexate

Outcome

  • N/A

Study Design

  • Dose Escalation

  • Cohort

Phase

  • NA

Study Id's

  • N/A

Sponsors

  • N/A

Result

  • N/A

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