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: The Nucleotide Kinase Nadk Is Required for ROS Detoxification and Constitutes a Metabolic Vulnerability of NOTCH1-Driven T-ALL

Researchers

Presenter

  • Etienne De Braekeleer

Principal Investigators

  • Joanne Hsu

  • Celine Hervieu

  • Konstantinos Tzelepis

  • Stefano Indraccolo

  • Alan J. Warren

  • Irmela Jeremias

  • David Fernandez Antoran

  • Phil H Jones

  • Margaret A. Goodell

  • George S. Vassiliou

Medical Centers

  • Wellcome Trust Sanger Institute, Cambridge, United Kingdom

  • Medical Scientist Training Program, Baylor College of Medicine, Houston, TX

  • Immunology and Molecular Oncology Unit, Veneto Institute of Oncology IOV-IRCCS, Padua, Italy

  • Department of Oncology, University of Cambridge, Cambridge, United Kingdom

  • Department of Apoptosis in Hematopoietic Stem Cells (AHS), Helmholtz Center München, Munich, Germany

  • Pre-Cancer,Wellcome Sanger Institute,Cambridge,United Kingdom

  • Department of Pediatrics, Stem Cells and Regenerative Medicine Center, Baylor College of Medicine, Houston, TX

  • Haematological Cancer Genetics,Wellcome Trust Sanger Institute,Cambridge,United Kingdom

  • Department of Haematology, Hills Road, Wellcome Trust-MRC Cambridge Stem Cell Institute, Cambridge, United Kingdom

Locations

  • United Kingdom

  • United States

  • Italy

  • Germany

Companies

  • N/A

Study Components

Therapeutic Area

  • Oncology (ONC)

Disease

  • T-cell acute lymphoblastic leukemia

  • Acute myelocytic leukemia

  • Solid malignancies

Biomarkers

  • B-cell lymphoma/leukemia 11B

  • Proto-oncogene tyrosine-protein kinase ROS

  • GATA Binding Protein 3

  • Glutathione

Drug/Treatment

  • Nicotinamide

  • glutathione

Outcome

  • N/A

Study Design

  • N/A

Phase

  • NA

Study Id's

  • N/A

Sponsors

  • N/A

Result

  • N/A

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