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: The Histone Demethylase KDM4A Is Required to Sustain H3K9me3/H3K27me3 Epigenetic States and Oncogenesis in MLL-AF9 Acute Myeloid Leukemia

Researchers

Presenter

  • Matthew E Massett

Principal Investigators

  • Niamh Mannion

  • Laura Monaghan

  • Joana Bittencourt-Silvestre

  • Sandra Marmiroli

  • Robert M J Liskamp

  • Alison M Michie

  • David Vetrie

  • Xu Huang

Medical Centers

  • Paul O?Gorman Leukaemia Research Centre, University of Glasgow, Glasgow, United Kingdom

  • Unit of Endocrinology, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy

  • Medicinal Chemistry Department, School of Chemistry, University of Glasgow, Glasgow, United Kingdom

  • Wolfson Wohl Cancer Research Centre, University of Glasgow, Glasgow, United Kingdom

Locations

  • United Kingdom

  • Italy

Companies

  • N/A

Study Components

Therapeutic Area

  • Oncology (ONC)

  • Urology

Disease

  • Acute myelocytic leukemia

  • Prostate cancer

  • Solid malignancies

Biomarkers

  • Cluster of Differentiation 34

  • Polycomb repressive complex 2

  • Enhancer of zeste homolog 2

  • Trimethylation of lysine 27 on histone H3

Drug/Treatment

  • Tazemetostat

  • EZH2

Outcome

  • N/A

Study Design

  • Cohort

Phase

  • NA

Study Id's

  • N/A

Sponsors

  • N/A

Result

  • N/A

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