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: Sphingosine-1-Phosphate Receptor 3 (S1PR3) Promotes Myeloid Commitment of Human Hematopoietic and Leukemic Stem Cells

Researchers

Presenter

  • Stephanie Zhi-Juan Xie

Principal Investigators

  • Kerstin Kaufmann

  • Olga I. Gan

  • Elisa Laurenti

  • Stanley W.K. Ng

  • Qiang Liu

  • Melissa Kleinau

  • Joseph Jargostf

  • Gareth Holmes

  • Chiara Luberto

  • Lina M Obeid

  • Yusuf A. Hannun

  • Jean C.Y. Wang

  • Mark D. Minden

  • John E. Dick

Medical Centers

  • Princess Margaret Cancer Centre University Health Network, Toronto, Ontario, Canada

  • Wellcome Trust-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom

  • Institute for Biomaterials & Biomedical Engineering, University of Toronto, Toronto, ON, Canada

  • University Health Network, Princess Margaret Cancer Centre, Toronto, ON, Canada

  • Stony Brook University School of Medicine, Stony Brook, NY

  • School of Medicine, Stony Brook University Medical Center, Stony Brook, NY

  • Stony Brook Cancer Center, Stony Brook University, Stony Brook, NY

  • Department of Surgery, University of Toronto, Toronto, ON, Canada

  • University Health Network, Princess Margaret Cancer Centre, Toronto, ON, Canada

  • Division of Medical Oncology and Hematology, Department of Medicine, Toronto, Canada

  • Princess Margaret Cancer Centre, Division of Medical Oncology and Hematology, University of Toronto, Toronto, Canada

  • Department of Surgery, University of Toronto, Toronto, ON, Canada

  • Medicine, Molecular Genetics, University of Toronto, Toronto, ON, Canada

Locations

  • Canada

  • United Kingdom

  • United States

Companies

  • N/A

Study Components

Therapeutic Area

  • Oncology (ONC)

Disease

  • Acute myelocytic leukemia

  • Solid malignancies

Biomarkers

  • Cluster of Differentiation 34

  • Cluster of Differentiation 38

  • Early Growth Response 1

  • Sphingosine-1-phosphate

  • Tribbles Pseudokinase 1

Drug/Treatment

  • FTY720

Outcome

  • N/A

Study Design

  • N/A

Phase

  • NA

Study Id's

  • N/A

Sponsors

  • N/A

Result

  • N/A

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