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: Hemoglobin S Induces Exposure of Red Blood Cell Membrane Skeleton Microdomains Bearing Mannose That Stimulate Phagocytosis By Macrophages: A Molecular Basis for Hemolysis in Sickle Cell Disease but Protection Against Plasmodium Falciparum malaria

Researchers

Presenter

  • Huan Cao

Principal Investigators

  • Megan A Forrester

  • Lindsay S Hall

  • Heather M Wilson

  • Jenna Shepherd

  • Bhinal Patel

  • Alanna Masson

  • Sadie Henderson

  • Gabriela Konieczny

  • Minter Beverly

  • Dimitrios Tampakis

  • Aristotelis Antonopoulos

  • Stuart M Haslam

  • Anne Dell

  • Alexandra J Rowe

  • John Brewin

  • David C Rees

  • Robert N Barker

  • Mark A Vickers

Medical Centers

  • University of Aberdeen, Aberdeen, Scotland, United Kingdom

  • Scottish National Blood Transfusion Service, Aberdeen, United Kingdom

  • Kingston University London, London, United Kingdom

  • Blood Transfusion Centre, ABERDEEN, United Kingdom

Locations

  • United Kingdom

Companies

  • N/A

Study Components

Therapeutic Area

  • Blood/haematological Diseases

  • Infectious Diseases (ID)

Disease

  • Sickle cell anemia

  • Alpha-thalassemia

  • Malaria

Biomarkers

  • Cluster of Differentiation 206

  • Lactate dehydrogenase

  • Stearoyl-CoA desaturase

  • Red Blood Cells

Drug/Treatment

  • N/A

Outcome

  • N/A

Study Design

  • N/A

Phase

  • NA

Study Id's

  • N/A

Sponsors

  • N/A

Result

  • N/A

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