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AEP281 : The MAFA gene mutation responsible for familial insulinomatosis and diabetes impairs insulin secretion and results in downregulation of critical cell cycle regulators

Researchers

Presenter

  • Donato Iacovazzo

Principal Investigators

  • Chung Thong Lim

  • Rosana Quezado

  • Juliana Drummond

  • Fernando Antonio de Sousa Barros

  • Joyceline Cuenco

  • Michael Brndle

  • Emily Walker

  • Min Guo

  • David Collier

  • Faraz Khan

  • Jun Wang

  • Tricia Tan

  • Sian Ellard

  • Roland Stein

  • Marta Korbonits

Medical Centers

  • Queen Mary University of London, Centre for Molecular Oncology, London, United Kingdom

  • Hospital Universitário Walter Cantídio, Serviço de Endocrinologia e Diabetes, Fortaleza, Brazil

  • Universidade Federal de Minas Gerais, Laboratory of Endocrinology, Belo Horizonte, Brazil

  • Imperial College, Section of Investigative Medicine, London, United Kingdom

  • Cantonal Hospital Street Gallen, Divison of Endocrinology and Diabetes, Street Gallen, Switzerland

  • Vanderbilt University, Department of Molecular Physiology and Biophysics, Nashville, United States

  • Queen Mary University of London, Centre for Molecular Oncology, London, United Kingdom

  • University of Exeter Medical School, Institute of Biomedical and Clinical Science, Exeter EX2 5DW, London, UK

Locations

  • United Kingdom

  • Brazil

  • Switzerland

  • United States

Companies

  • N/A

Study Components

Therapeutic Area

  • Endocrine/metabolic Diseases (ME)

Disease

  • Insulinomatosis and diabetes mellitus

  • Prediabetes

  • Diabetes

  • Hyperinsulinism

Biomarkers

  • C-peptide

  • Forkhead box M1

  • Insulin

  • Body mass index

Drug/Treatment

  • Intranasal glucagon

  • INS-1

Outcome

  • N/A

Study Design

  • N/A

Phase

  • NA

Study Id's

  • N/A

Sponsors

  • N/A

Result

  • N/A

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