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AEP275 : Female AKR1D1 knockout mice have impaired intestinal health with evidence of gut dybiosis, increased gut permeability and an increased incidence of colon cancer

Researchers

Presenter

  • Anastasia Arvaniti

Principal Investigators

  • Shelley Harris

  • Nikolaos Nikolaou

  • Tom Potter

  • Roger Cox

  • Alex Odermatt

  • Jeremy Tomlinson

  • Laura Gathercole

Medical Centers

  • Oxford Brookes University, Department of Biological and Medical Sciences, Oxford, United Kingdom

  • University of Oxford, Oxford Centre for Diabetes, Endocrinology and Metabolism, Oxford, United Kingdom

  • MRC Harwell Institute, Oxfordshire, , United Kingdom

  • University of Basel, Department of Pharmaceutical Sciences, Basel, Switzerland

Locations

  • United Kingdom

  • Switzerland

Companies

  • N/A

Study Components

Therapeutic Area

  • Gastroenterology (GU)

Disease

  • Nonalcoholic fatty liver disease

  • Metabolic syndrome

  • Colorectal Cancer

  • Fatty Liver Disease

  • Dysbiosis

  • Solid malignancies

Biomarkers

  • Claudin1

  • Toll like receptor 4

Drug/Treatment

  • Occlusal-HP Topical

Outcome

  • N/A

Study Design

  • N/A

Phase

  • NA

Study Id's

  • N/A

Sponsors

  • N/A

Result

  • N/A

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