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691 : Setbp1 Overexpression Acts in the Place of Class-Defining Somatic Mutations to Drive Mouse and Human FLT3-ITD-Mutant AMLs

Researchers

Presenter

  • Suruchi Pacharne

Principal Investigators

  • Oliver M. Dovey

  • Jonathan L Cooper

  • Muxin Gu

  • Vijay Baskar

  • Mathias J Friedrich

  • Malgorzata Gozdecka

  • Sandeep S Rajan

  • Etienne De Braekeleer

  • Maxim Barenboim

  • Grace Collord

  • Hannes Postingl

  • Ruben Bautista

  • Milena Mazan

  • Roland Rad

  • Konstantinos Tzelepis

  • Penny Wright

  • George S. Vassiliou

Medical Centers

  • WELLCOME TRUST SANGER INSTITUTE, Cambridgeshire, United Kingdom

  • Wellcome Trust Sanger Institute, Cambridge, United Kingdom

  • Wellcome Trust Sanger Institute, Cambridge, United Kingdom

  • Wellcome-MRC Cambridge Stem Cell Institute, Cambridge, United Kingdom

  • 3rd Department of Internal Medicine, Klinikum Rechts der Isar der Technischen Universität München, Munich, Germany

  • Haematological Cancer Genetics,Wellcome Trust Sanger Institute,Cambridge,United Kingdom

  • UK Dementia Research Institute at the University of Cambridge, Cambridge, United Kingdom

  • Klinikum rechts der Isar, Technical University Munich, Munich, Germany

  • Wellcome Trust Sanger Institute, Cambridge, United Kingdom

  • Selvita S.A., Krakow, Poland.

  • Institute of Molecular Oncology and Functional Genomics, Technical University of Munich, Munich, Germany

  • Cambridge University Hospitals NHS Trust, Cambridge, GBR

  • Wellcome Trust Sanger Institute, Cambridge, United Kingdom

Locations

  • United Kingdom

  • Germany

  • Poland

Companies

  • Wellcome Sanger Inst

Study Components

Therapeutic Area

  • Oncology (ONC)

  • Blood/haematological Diseases

Disease

  • Acute myelocytic leukemia

  • Acute Leukemia

Biomarkers

  • Nucleophosmin 1

  • CCAAT enhancer binding protein alpha

  • ETV6-RUNX1

  • Histone-lysine N-methyltransferase 2A

Drug/Treatment

  • oryzanol

  • Grace

  • EZH2

Outcome

  • N/A

Study Design

  • N/A

Phase

  • NA

Study Id's

  • N/A

Sponsors

  • N/A

Result

  • N/A

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