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3079 : The BET Inhibitor, CPI-0610, Promotes Myeloid Differentiation in Myelofibrosis Patient Bone Marrow and Peripheral CD34+ Hematopoietic Stem Cells

Researchers

Presenter

  • Jennifer A Mertz

Principal Investigators

  • Rosana D Meyer

  • Oksana Zavidij

  • Jike Cui

  • Jean-Jacques Kiladjian

  • Srdan Verstovsek

  • Vikas Gupta

  • Moshe Talpaz

  • Claire Harrison

  • Adam J. Mead

  • Ruben Mesa

  • John Mascarenhas

  • Adrian Senderowicz

  • Gozde Colak

  • James Shao

  • Katarina Luptakova

  • Jeffrey S Humphrey

  • Jing Wang

  • Patrick Trojer

  • Mohamed E Salama

Medical Centers

  • Constellation Pharmaceuticals, Inc., Cambridge, MA

  • Clinical Investigations Center, Saint-Louis hospital, Université de Paris, Paris, France

  • Department of Bioinformatics, The University of Texas MD Anderson Cancer Center, Houston, TX

  • Princess Margaret Cancer Centre, University of Toronto, Toronto, ON, Canada

  • Rogel Cancer Center, The University of Michigan, Ann Arbor, MI

  • Guy's And St Thomas NHS Foundation Trust, London, United Kingdom

  • Oxford University Hospitals NHS Trust, Oxford, United Kingdom

  • Mays Cancer Center, UT Health San Antonio, San Antonio, TX, USA

  • Division of Hematology and Medical Oncology, Icahn School of Medicine at Mount Sinai / The Tisch Cancer Institute, New York, NY

  • Constellation Pharmaceuticals, CAMBRIDGE, MA

  • Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN

Locations

  • United States

  • France

  • Canada

  • United Kingdom

Companies

  • N/A

Study Components

Therapeutic Area

  • Blood/haematological Diseases

Disease

  • Myelofibrosis

  • Anemia

Biomarkers

  • Cluster of Differentiation 34

  • Integrin subunit beta 3

  • Interleukin 6

  • Interleukin-9

  • TIMP Metallopeptidase Inhibitor 1

Drug/Treatment

  • Ruxolitinib phosphate

  • CPI-0610

Outcome

  • N/A

Study Design

  • N/A

Phase

  • NA

Study Id's

  • NCT02158858

Sponsors

  • N/A

Result

  • N/A

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