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555 : The Enhanced Functionality of Low-Affinity CD19 CAR T Cells Is Associated with Activation Priming and Polyfunctional Cytokine Phenotype

Researchers

Presenter

  • Ilaria M. Michelozzi

Principal Investigators

  • Eduardo Gomez-Castaneda

  • Ruben V.C. Pohle

  • Ferran Cardoso Rodriguez

  • Jahangir Sufi

  • Pau Puigdevall

  • Meera Subramaniyam

  • Si Wei Wu

  • Aleks Guvenel

  • Sara Ghorashian

  • Martin Pule

  • Christopher J. Tape

  • Sergi Castellano

  • Persis J Amrolia

  • Alice Giustacchini

Medical Centers

  • Molecular and Cellular Immunology Section, UCL Great Ormond Street Institute of Child Health, London, ENG, United Kingdom

  • Molecular and Cellular Immunology Section, UCL Great Ormond Street Institute of Child Health, London, ENG, United Kingdom

  • Cell Communication Lab, Department of Oncology, University College London Cancer Institute, London, United Kingdom

  • Department of Pediatric Anesthesiology, Great Ormond Street Hospital,NHS, London, United Kingdom

  • Nephrology Unit, Developmental Biology and Cancer Program, UCL Great Ormond Street Institute of Child Health, London, United Kingdom

  • Bart's Cancer Institute, London, United Kingdom

  • Bone Marrow Transplantation Department, Great Ormond Street hospital NHS Trust, London, United Kingdom

Locations

  • United Kingdom

Companies

  • N/A

Study Components

Therapeutic Area

  • N/A

Disease

  • N/A

Biomarkers

  • Mitogen-activated protein kinase

  • p38 Mitogen-activated protein kinases

  • Catalase

  • Perforin 1

  • C-C Motif Chemokine Ligand 4

  • Cluster of Differentiation 25

  • Cluster of Differentiation 2AP

  • Cluster of Differentiation 4

  • Cluster of differentiation 8A

  • Coxsackie Virus And Adenovirus Receptor

  • C-X-C motif chemokine ligand 8

  • Cytokine

  • Granulocyte-macrophage-colony stimulating factor

  • Granzyme B

  • Interferon-gamma

  • T-cell receptor

Drug/Treatment

  • tisagenlecleucel-t

Outcome

  • N/A

Study Design

  • N/A

Phase

  • I

Study Id's

  • N/A

Sponsors

  • N/A

Result

  • N/A

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