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384 : Aging of Preleukemic Thymocytes Drives CpG Island Hypermethylation in T-Cell Acute Lymphoblastic Leukemia

Researchers

Presenter

  • Juliette Roels

Principal Investigators

  • Bronislawa Szarzynska

  • Mattias Landfors

  • Stien De Coninck

  • Lisa Demoen

  • Lien Provez

  • Anna Kuchmiy

  • Steven Strubbe

  • Lindy Reunes

  • Tim Pieters

  • Filip Matthijssens

  • Wouter Van Loocke

  • Tim Lammens

  • Barbara De Moerloose

  • Marc R. Mansour

  • Utpal Dave

  • Steven Goossens

  • David J. Curtis

  • Tom Taghon

  • Malgorzata Dawidowska

  • Sofie Degerman

  • Pieter Van Vlierberghe

Medical Centers

  • Centre for Medical Genetics, Ghent University Hospital, Ghent, Belgium

  • Cancer Research Institute Ghent (CRIG), Ghent University, Ghent, Belgium

  • Department of Biomolecular Medicine,Ghent University,Ghent,Belgien

  • Institute of Human Genetics Polish Academy of Sciences,Poznan,Polen

  • Department of Medical Bioscience/Medical and Clinical Genetics, UmeÃ¥ University, UmeÃ¥, Sweden

  • Department of Diagnostic Sciences,Ghent University,Ghent,Belgium

  • Department of Pediatric Hematology-Oncology and Stem Cell Transplantation, Ghent University Hospital, Ghent, Belgium

  • Cancer Research Institute Ghent (CRIG), Ghent, Belgium

  • Department of Pediatric Hematology-Oncology and Stem Cell Transplantation, Ghent University Hospital, Ghent, Belgium

  • Belgium Society of Paediatric Hematology Oncology, Ghent, Belgium

  • Department of Haematological Medicine, King's College London, London, United Kingdom

  • Department of Urology, Indiana University School of Medicine, Indianapolis, IN

  • IU Melvin and Bren Simon Cancer Center; Division of Hematology/Oncology, Vanderbilt University Medical Center, Indianapolis, IN

  • Australian Centre For Blood Diseases, Monash University, Melbourne, Australia

Locations

  • Belgium

  • Poland

  • Sweden

  • United Kingdom

  • United States

  • Australia

Companies

  • N/A

Study Components

Therapeutic Area

  • Oncology (ONC)

Disease

  • T-cell acute lymphoblastic leukemia

  • Solid malignancies

Biomarkers

  • Polycomb repressive complex 2

  • cMYC

  • DNA methylation

  • Trimethylation of lysine 27 on histone H3

Drug/Treatment

  • Decitabine

Outcome

  • N/A

Study Design

  • N/A

Phase

  • I

Study Id's

  • N/A

Sponsors

  • N/A

Result

  • N/A

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