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2297 : Effect of Prior Treatment with Proteasome Inhibitors on the Efficacy and Safety of Once-Weekly Selinexor, Bortezomib, and Dexamethasone in Comparison with Twice-Weekly Bortezomib and Dexamethasone in Relapsed or Refractory Multiple Myeloma: Subgroup Analysis from the Boston Study

Researchers

Presenter

  • Maria Mateos

Principal Investigators

  • Thierry Facon

  • Holger W Auner

  • Xavier Leleu

  • Roman Hajek

  • Meletios A Dimopoulos

  • Sosana Delimpasi

  • Maryana Simonova

  • Ivan Spicka

  • Ludek Pour

  • Irina Kryachok

  • Halyna Pylypenko

  • Vadim A Doronin

  • Ganna Usenko

  • Reuben Benjamin

  • Tuphan Kanti Dolai

  • Dinesh Kumar Sinha

  • Christopher P. Venner

  • Mamta Garg

  • Don A. Stevens

  • Hang Quach

  • Sundar Jagannath

  • Philippe Moreau

  • Moshe Levy

  • Ashraf Z. Badros

  • Larry D. Anderson Jr

  • Nizar Bahlis

  • Michele Cavo

  • Yi Chai

  • Melina Arazy

  • Jatin Shah

  • Sharon Shacham

  • Michael G Kauffman

  • Paul G. Richardson

  • Sebastian Grosicki

Medical Centers

  • Hospital Universitario De Salamanca-IBSAL, Salamanca, Spain

  • School of Medicine, National and Kapodistrian University of Athens, Athens, Greece

  • Centre Hospitalier Universitaire (CHU) Lille, Service des Maladies du Sang, University of Lille, Lille, France

  • Imperial College, London, United Kingdom

  • CHU de Poitiers - Hôpital La Milétrie, Service d'Hématologie et Thérapie Cellulaire, Pôle Régional de Cancérologie, POITIERS, France

  • University Hospital, Ostrava, Czech Republic

  • Athens School of Medicine, Athens, Greece

  • Department of Hematology and Bone Marrow Transplantation Unit, Evangelismos Hospital, Athens, Greece

  • Institute of Blood Pathology and Transfusion Medicine of the Academy of Medical Sciences of Ukraine, Lviv, Ukraine

  • Charles University General Hospital in Prague, Prague, Czech Republic.

  • University Hospital Brno, Brno, Czech Republic

  • Oncohematology, National Cancer Instititute, Kyiv, Ukraine

  • Department of Hematology, Regional Treatment and Diagnostics Hematology Centre,Cherkasy Regional Oncology Centre,Cherkasy,Ucraina

  • Hematology Department, State Budget Healthcare Institution of Moscow, City Clinical Hospital #40 of Moscow Healthcare Department, Moscow, Russian Federation

  • City Clinical Hospital No. 4 of Dnipro City Council, City Hematology Center, Dnipro, Ukraine

  • King's College Hosptial NHS Foundation Trust, London, United Kingdom

  • Hematology, NRS Medical College, Kolkata, India

  • Indira Gandhi Institue of Medical Sciences, Patna, India

  • Cross Cancer Institute, University of Alberta, Edmonton, AB, Canada

  • University Hospitals Leicester NHS Trust, Leicester, United Kingdom

  • Norton Cancer Institute - St Matthews Campus, Louisville, KY

  • St Vincent's Hospital, Fitzroy, Australia

  • Icahn School of Medicine at Mount Sinai, New York, NY

  • Department of Hematology, CHU Nantes, Nantes, France

  • Baylor University Medical Center, Dallas, TX

  • University of Maryland Greenebaum Comprehensive Cancer Center (UMGCCC), Baltimore, MD

  • UT Southwestern Simmons Comprehensive Cancer Center, Dallas, TX

  • University of Calgary, Calgary, AB, Canada

  • Seragnoli Institute of Hematology, Bologna University School of Medicine, Bologna, Italy

  • Karyopharm Therapeutics, Newton, MA

  • Karyopharm Therapeutics, Newton, MA

  • Dana-Farber Cancer Institute, Boston, MA

  • Silesian Medical University, Katowice, Poland,

Locations

  • Spain

  • Greece

  • France

  • United Kingdom

  • Czech Republic

  • Ukraine

  • Russia

  • India

  • Canada

  • United States

  • Australia

  • Italy

  • Poland

Companies

  • Karyopharm Therapeut

Study Components

Therapeutic Area

  • Oncology (ONC)

Disease

  • Multiple Myeloma

Biomarkers

  • N/A

Drug/Treatment

  • Dexamethasone

  • Dekpak 13 Day Taperpak

  • Bortezomib

  • Selinexor

Outcome

  • N/A

Study Design

  • Randomized

  • Open Label

Phase

  • III

Study Id's

  • N/A

Sponsors

  • N/A

Result

  • N/A

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