// App-Quantinova.ai

1682 : Trial in Progress: The Phase III, Randomized, Open-Label, Multicenter COMMODORE 2 Study Evaluating the Efficacy and Safety of Crovalimab Versus Eculizumab in Adult and Adolescent Patients with Paroxysmal Nocturnal Hemoglobinuria Not Previously Treated with Complement Inhibitors

Researchers

Presenter

  • Austin G Kulasekararaj

Principal Investigators

  • Guangsheng He

  • Talha Munir

  • Jeffrey Pu

  • Antonio Risitano

  • Alexander Rth

  • Camelia S. Sima

  • Anita Appius

  • Alexandre Sostelly

  • Sasha Sreckovic

  • Charlotte Vignal

  • Jun-Ichi Nishimura

Medical Centers

  • King’s College Hospital NHS Foundation Trust, King’s College, London, UK, and NIHR Wellcome King’s Clinical Research Facility, London, United Kingdom

  • Department of Hematology, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, Nanjing, China

  • St. James's University Hospital, Leeds, United Kingdom

  • Hollings Cancer Center, Medical University of South Carolina, Charleston, SC

  • Department of Clinical Medicine and Surgery, Federico II University, Naples, Italy

  • Hematology and BMT Unit,AORN Moscati Avellino,Avellino,Italy

  • Department of Dermatology, University Hospital, University Duisburg-Essen, Essen, Germany

  • Genentech, Inc., South San Francisico, CA

  • F. Hoffmann-La Roche Ltd., Basel, Switzerland

  • Department of Pathologic Oncology, Mie University Graduate School of Medicine, Mie, Japan

Locations

  • United Kingdom

  • China

  • United States

  • Italy

  • Germany

  • Switzerland

  • Japan

Companies

  • Genentech, Inc.

  • F. Hoffmann-La Roche

Study Components

Therapeutic Area

  • Blood/haematological Diseases

Disease

  • Paroxysmal nocturnal hemoglobinuria

Biomarkers

  • N/A

Drug/Treatment

  • Eculizumab

Outcome

  • N/A

Study Design

  • Randomized

  • Pharmacokinetics

  • Open Label

  • Non Inferiority

  • Multicenteric

  • Controlled

Phase

  • III

Study Id's

  • NCT03157635

  • NCT04434092

Sponsors

  • N/A

Result

  • N/A

Copyright © 2026. QuantiNova All rights reserved