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117 : LOXO-305, A Next Generation, Highly Selective, Non-Covalent BTK Inhibitor in Previously Treated Mantle Cell Lymphoma, Waldenström's Macroglobulinemia, and Other Non-Hodgkin Lymphomas: Results from the Phase 1/2 BRUIN Study

Researchers

Presenter

  • Michael Wang

Principal Investigators

  • Alvaro J. Alencar

  • James N. Gerson

  • Manish R. Patel

  • Bita Fakhri

  • Wojciech Jurczak

  • Xuan Ni Tan

  • Katharine L Lewis

  • Timothy S. Fenske

  • Catherine C. Coombs

  • Ian W. Flinn

  • David John Lewis

  • Steven Le Gouill

  • M. Lia Palomba

  • Jennifer A. Woyach

  • John M. Pagel

  • Nicole Lamanna

  • Jonathon B. Cohen

  • Minal Barve

  • Paolo Ghia

  • Toby A. Eyre

  • Ming Yin

  • Binoj Nair

  • Donald Tsai

  • Nora C. Ku

  • Anthony Mato

  • Chan Yoon Cheah

Medical Centers

  • Department of Lymphoma and Myeloma, University of Texas M. D. Anderson Cancer Center, Houston, TX

  • Med Coll of Wisconsin, Brookfield, WI

  • Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL

  • Lymphoma Program, Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA

  • Florida Cancer Specialists and Research Institute, Sarasota, FL

  • Division of Rheumatology, University of California, San Francisco, CA

  • Linear Clinical Research/Sir Charles Gairdner Hospital, Nedlands, Australia

  • Department of Hematology and Oncology, Medical College of Wisconsin, Milwaukee, WI

  • Lineberger Comprehensive Cancer Center at the University of North Carolina, Chapel Hill, NC

  • Sarah Cannon Research Institute/Tennessee Oncology, PLLC, Nashville, TN

  • Plymouth Hospitals NHS Trust - Derriford Hospital ,Plymouth,United Kingdom

  • Service d’hématologie clinique du CHU de Nantes, INSERM CRCINA Nantes-Angers, NeXT Université de Nantes, Nantes, France

  • Memorial Sloan Kettering Cancer Center, Port Washington, NY

  • The Ohio State University Comprehensive Cancer Center, Columbus, OH

  • Center for Blood Disorders and Stem Cell Transplantation, Swedish Cancer Institute,Seattle,Estados Unidos

  • Department of Medicine, Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, NY

  • Winship Cancer Institute of Emory University, Atlanta, GA

  • Mary Crowley Cancer Research Centers, Dallas, TX

  • Università Vita-Salute San Raffaele and IRCCS Ospedale San Raffaele, Milan, Italy

  • Churchill Cancer Center, Oxford University Hospitals NHS Foundation Trust, Old Road, United Kingdom

  • Loxo Oncology at Lilly,Stamford,USA

Locations

  • United States

  • Poland

  • Australia

  • United Kingdom

  • France

  • Italy

Companies

  • N/A

Study Components

Therapeutic Area

  • Oncology (ONC)

Disease

  • Mantle cell lymphoma

  • B cell lymphomas

  • Hodgkin's Lymphoma

  • Non‐Hodgkin Lymphoma

  • Lymphomas

Biomarkers

  • Bruton tyrosine kinase

Drug/Treatment

  • N/A

Outcome

  • N/A

Study Design

  • Multicenteric

  • Dose Escalation

Phase

  • I/II

Study Id's

  • N/A

Sponsors

  • N/A

Result

  • N/A

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