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108 : High-Density Domain-Focused CRISPR Screens Reveal Epigenetic Regulators of Hox/Meis Gene Expression in Acute Myeloid Leukemia

Researchers

Presenter

  • Karina Barbosa

Principal Investigators

  • Anagha Deshpande

  • Ping Xiang

  • Bo-Rui Chen

  • Adam Brown

  • Neil Robertson

  • Younguk Sun

  • John Doench

  • Peter D Adams

  • R. Keith Humphries

  • Prashant Mali

  • Aniruddha J. Deshpande

Medical Centers

  • Tumor Initiation and Maintenance Program, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA

  • Sanford Burnham Prebys Medical Discovery Institute, Heidelberg, CA

  • Terry Fox Laboratory, BC Cancer Agency, Vancouver, BC, Canada

  • Broad Institute, Cambridge, MA

  • Institute of Cancer Science, University of Glasgow, Glasgow, United Kingdom

  • Department of Bioengineering, University of California and San Diego, La Jolla, CA

Locations

  • United States

  • Canada

  • United Kingdom

Companies

  • N/A

Study Components

Therapeutic Area

  • Genetic Disorder

  • Musculoskeletal

Disease

  • Acute myelocytic leukemia

  • Solid malignancies

  • Myopathy with exercise intolerance Swedish type

Biomarkers

  • Casein Kinase II

Drug/Treatment

  • CX4945

  • Casein

Outcome

  • N/A

Study Design

  • N/A

Phase

  • II

Study Id's

  • N/A

Sponsors

  • N/A

Result

  • N/A

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