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1304 : IKZF3 Overexpression Phenocopies Gain-of-Function Mutation in Chronic Lymphocytic Leukemia

Researchers

Presenter

  • Shanye Yin

Principal Investigators

  • Gregory Lazarian

  • Elisa Ten Hacken

  • Tomasz Sewastianik

  • Satyen Gohil

  • Shuqiang Li

  • Laura Z. Rassenti

  • Leah Billington

  • Elizabeth Witten

  • Teddy Huang

  • Kenneth J. Livak

  • Donna S. Neuberg

  • Fanny Baran-Marszak

  • Thomas J. Kipps

  • Florence Cymbalista

  • Ruben D. Carrasco

  • Catherine J. Wu

Medical Centers

  • Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA

  • Department of Medical Oncology, Dana-Farber Cancer Institute, PARIS, France

  • Laboratoire -Hematologie Biologique, Hopital Avicenne, Bobigny, France

  • Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA

  • Department of Hematology, Institute of Hematology and Transfusion Medicine, Warszawa,

  • University Ci, Enfield, United Kingdom

  • Translational Immunogenomics Lab, Dana-Farber Cancer Institute, Boston, MA

  • Moores Cancer Center, University of California, San Diego, La Jolla, CA

  • Department of Imaging, Dana-Farber Cancer Institute, Boston, MA

  • UC San Diego Moores Cancer Center, San Diego, CA

  • Department of Oncologic Pathology, Dana-Farber Cancer Institute, Boston, MA

  • Department of Medicine, Brigham and Women's Hospital, Boston, MA

  • Broad Institute of MIT and Harvard, Cambridge, MA

  • Dana-Farber Cancer Institute, Boston, MA

Locations

  • United States

  • France

  • Poland

  • United Kingdom

Companies

  • N/A

Study Components

Therapeutic Area

  • Oncology (ONC)

Disease

  • Chronic Lymphocytic Leukemia

  • Solid malignancies

Biomarkers

  • NF-kappa-B inhibitor alpha

  • Rac Family Small GTPase 1

  • Immunoglobulin heavy-chain variable region gene

Drug/Treatment

  • fludarabine tablet

  • Ibrutinib

Outcome

  • N/A

Study Design

  • Cohort

Phase

  • NA

Study Id's

  • N/A

Sponsors

  • N/A

Result

  • N/A

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