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O31 : IL-27 regulates the magnitude of ectopic germinal centres in experimental sialadenitis but fails to modulate IL-17 and IFNg production in CD4 T cells from patients with Sjögren's syndrome

Researchers

Presenter

  • Davide Lucchesi

Principal Investigators

  • Rachel Coleby

  • Elena Pontarini

  • Edoardo Prediletto

  • Felice Rivellese

  • David Hill

  • Alicia Derrac Soria

  • Simon Jones

  • Ian Humphreys

  • Nurhan Sutcliffe

  • Anwar Tappuni

  • Costantino Pitzalis

  • Gareth Jones

  • Michele Bombardieri

Medical Centers

  • William Harvey Research Institute, Centre for Experimental Medicine and Rheumatology, Queen Mary University of London, London, United Kingdom

  • Division of Infection and Immunity, Cardiff University, Cardiff, UNITED KINGDOM

  • Department of Rheumatology, Bolton NHS Trust, Bolton, UNITED KINGDOM

  • Department of Oral Medicine, Queen Mary University of London, London, UNITED KINGDOM

Locations

  • United Kingdom

Companies

  • N/A

Study Components

Therapeutic Area

  • Autoimmune (AI)

Disease

  • Rheumatoid arthritis

  • Sjogren's syndrome

  • Inflammatory Arthritis

Biomarkers

  • Peripheral blood mononuclear cell

  • Cluster of Differentiation 4

  • Interleukin 17A

  • Interleukin 27

Drug/Treatment

  • N/A

Outcome

  • N/A

Study Design

  • N/A

Phase

  • NA

Study Id's

  • N/A

Sponsors

  • N/A

Result

  • N/A

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