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O07 : Randomised, open labelled clinical trial to investigate synovial mechanisms determining response: resistance to rituximab versus tocilizumab in RA patients failing TNF inhibitor therapy

Researchers

Presenter

  • Frances C Humby

Principal Investigators

  • Patrick Durez

  • Maya H Buch

  • Michele Bombardieri

  • Hasan Rizvi

  • Felice Rivellese

  • Liliane Fossati

  • Rebecca Hands

  • Giovanni Giorli

  • Chris John

  • Arti Mahto

  • Stephen Kelly

  • Alessandra Nerviani

  • Carlomaurizio Montecucco

  • Bernard Lauwerys

  • Nora Ng

  • Georgina Thornborn

  • Vasco C Romao

  • Pauline Ho

  • Patrick Verschueren

  • Pier Paolo Sainaghi

  • Mattia Bellan

  • Serena Bugatti

  • Arthur G Pratt

  • Christopher Holyroyd

  • Mattia Congia

  • Charlie Thompson

  • Nagui Gendi

  • Bhaskar Dasgupta

  • Alberto Cauli

  • Piero Reynolds

  • Juan Caete

  • Robert J Moots

  • Peter C Taylor

  • Christopher Edwards

  • John Isaacs

  • Peter Sasieni

  • Joao Eurico Fonseca

  • Ernest Choy

  • Costantino Pitzalis

Medical Centers

  • Queen Mary University of London, UNITED KINGDOM, Queen Mary University of London, UNITED KINGDOM

  • Pôle de Recherche en Rhumatologie, Institut de Recherche Expérimentale et Clinique, UCL Saint-Luc, Brussels, Belgium

  • University of Leeds & NIHR Leeds Biomedical Research Centre, UNITED KINGDOM

  • Barts Health NHS Trust, London, UNITED KINGDOM

  • University of Pavia, Pavia, Italy

  • Faculty of Medicine, Catholic University of Louvain, London, BELGIUM

  • Guys and St Thomas NHS Trust, London, UK

  • University of Lisbon, PORTUGAL

  • Reader, University of Manchester, Manchester, UNITED KINGDOM

  • Skeletal Biology and Engineering Research Center, University of Leuven, Leuven, BELGIUM

  • University of Novara, Novara, ITALY

  • Newcastle University, Newcastle, UNITED KINGDOM

  • University of Southampton, UNITED KINGDOM

  • University of Cagliari, ITALY

  • University of Cardiff, UNITED KINGDOM

  • Basildon and Thurrock University Hospitals NHS Foundation Trust, Basildon, United Kingdom

  • Southend University Hospital NHS Trust, London, UNITED KINGDOM

  • University Clinic AOU and University of Cagliari

  • Homerton University NHS Trust, UNITED KINGDOM

  • Rheumatology Department, Hospital Clínic and IDIBAPS

  • Institute of Ageing and Chronic Disease, University of Liverpool, UNITED KINGDOM

  • University of Oxford, Oxford, UNITED KINGDOM

  • Kings College London, UNITED KINGDOM

  • Rheumatology and Bone Diseases Department, Hospital de Santa Maria, Centro Hospitalar Universitário Lisboa Norte; Unidade de Investigação em Reumatologia, Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa; Centro Académico de Medicina de Lisboa; Lisbon, Portugal., Lisbon, Portugal

  • Cardiff University School Of Medicine

Locations

  • United Kingdom

  • Italy

  • Belgium

  • Portugal

Companies

  • N/A

Study Components

Therapeutic Area

  • N/A

Disease

  • N/A

Biomarkers

  • Tumor necrosis factor

Drug/Treatment

  • Tocilizumab

  • Rituximab

Outcome

  • N/A

Study Design

  • Randomized

  • Open Label

  • Superiority

Phase

  • IV

Study Id's

  • N/A

Sponsors

  • N/A

Result

  • N/A

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