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447 : DNA methyltransferase inhibitor guadecitabine combined with cisplatin and gemcitabine chemotherapy (SPIRE): Randomized expansion phase as neoadjuvant therapy for bladder urothelial carcinoma.

Researchers

Presenter

  • Simon J. Crabb

Principal Investigators

  • Sarah Danson

  • James WF Catto

  • Syed A. Hussain

  • Denise Dunkley

  • Nichola Downs

  • Geoff Saunders

  • Michelle Light

  • Naveed Sarwar

  • Deborah Enting

  • Alison Jane Birtle

  • Amir El Ghzal

  • Bernadette Johnson

  • Robert A Huddart

  • Gareth Owen Griffiths

Medical Centers

  • Southampton Experimental Cancer Medicine Centre, Southampton, United Kingdom

  • Sheffield Experimental Cancer Medicine Centre, Weston Park Hospital, Sheffield, United Kingdom

  • Academic Radiology, The University of Sheffield, Sheffield, United Kingdom,

  • University of Liverpool, Clatterbridge Cancer Centre NHS Foundation Trust, Wirral, United Kingdom

  • Southampton Clinical Trials Unit, University of Southampton, University Hospital Southampton NHS Foundation Trust and Southampton Experimental Cancer Medicine Centre, Southampton, United Kingdom

  • Southampton Clinical Trials Unit, University of Southampton and University Hospital Southampton NHS Foundation Trust, Southampton, United Kingdom

  • University of Southampton Hospital Trust, Southampton, United Kingdom

  • Imperial College, London, United Kingdom

  • Guy's And St Thomas NHS Foundation Trust, London, United Kingdom

  • Rosemere Cancer Centre, Royal Preston Hospital, Preston, United Kingdom

  • The Institute of Cancer Research, Sutton, United Kingdom

  • The Royal Marsden Hospital NHS Foundation Trust, London & Surrey, United Kingdom

  • The Institute of Cancer Research, The Royal Marsden NHS Foundation Trust, Sutton, United Kingdom

  • Southampton Clinical Trials Unit,University of Southampton, Southampton, United Kingdom

Locations

  • United Kingdom

Companies

  • N/A

Study Components

Therapeutic Area

  • Oncology (ONC)

Disease

  • Bladder Cancer

  • Solid malignancies

Biomarkers

  • Granulocyte colony-stimulating factor

  • Long interspersed nucleotide element-1

Drug/Treatment

  • guadecitabine

  • Gemcitabine

  • Cisplatin

  • Filgrastim

Outcome

  • N/A

Study Design

  • Randomized

  • Pharmacodynamics

  • Open Label

Phase

  • NA

Study Id's

  • N/A

Sponsors

  • N/A

Result

  • N/A

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