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450 : 1L pembrolizumab (pembro) versus chemotherapy (chemo) for choice-of-carboplatin patients with advanced urothelial carcinoma (UC) in KEYNOTE-361.

Researchers

Presenter

  • Thomas Powles

Principal Investigators

  • Mustafa Ozguroglu

  • Nobuaki Matsubara

  • Lajos Geczi

  • Susanna Y. Cheng

  • Yves Fradet

  • Stephane Oudard

  • Christof Vulsteke

  • Rafael Morales-Barrera

  • Aude Flechon

  • Seyda Gunduz

  • Yohann Loriot

  • Alejo Rodriguez-Vida

  • Ronac Mamtani

  • Evan Y. Yu

  • Kijoeng Nam

  • Kentaro Imai

  • Blanca Homet Moreno

  • Ajjai Shivaram Alva

Medical Centers

  • Barts Cancer Institute, Queen Mary University of London, London, United Kingdom

  • Hetenyi G Korhaz, Szolnok, Hungary

  • Istanbul University, Cerrahpasa School of Medicine, Istanbul, Turkey

  • Division of Breast and Medical Oncology, National Cancer Center Hospital East, Chiba, Japan

  • National Institute of Oncology, Budapest, Hungary

  • Sunnybrook Odette Cancer Centre, Toronto, ON, Canada

  • CHU de Quebec - Universite Laval, Quebec City, QC, Canada

  • Oncology Department, Hôpital Européen Georges Pompidou, AP-HP, University of Paris, Paris, France

  • Center for Oncological Research (CORE), University of Antwerp, Integrated Cancer Center Ghent, Ghent, Belgium

  • Vall d'Hebron Institute of Oncology, Barcelona, Spain

  • Department of Thoracic Oncology, Centre Leon Berard, Lyon, France

  • Akdeniz University, Antalya, Turkey

  • Department of Cancer Medicine, Institut Gustave Roussy, Paris-Sud University, Villejuif, France

  • Medical Oncology Department, Hospital del Mar Research Institute, Barcelona, Spain

  • University of Pennsylvania, Philadelphia, PA

  • Division of Medical Genetics, Department of Medicine, University of Washington, Seattle, WA

  • Merck & Co., Inc., Kenilworth, NJ

  • University of Michigan Comprehensive Cancer Center, Ann Arbor, MI

Locations

  • United Kingdom

  • Hungary

  • Turkey

  • Japan

  • Canada

  • France

  • Belgium

  • Spain

  • United States

Companies

  • Merck & Co., Inc.

Study Components

Therapeutic Area

  • Oncology (ONC)

  • Urology

Disease

  • Advanced Urothelial Carcinoma

Biomarkers

  • N/A

Drug/Treatment

  • Pembrolizumab

  • Carboplatin

  • Gemcitabine

  • Cisplatin

Outcome

  • N/A

Study Design

  • Double Blind/Blinded

Phase

  • III

Study Id's

  • NCT02853305

Sponsors

  • N/A

Result

  • N/A

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