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801 ⋆ : Heterozygous Carriage of the Alpha1‐ antitrypsin PiZ Variant Increases the Risk to Develop Liver Fibrosis

Researchers

Presenter

  • Pavel Strnad

Principal Investigators

  • Karim Hamesch

  • Janett Fischer

  • Jonas Rosendahl

  • Renate Schmelz

  • Stefan Brueckner

  • Mario Brosch

  • Marla Gutberlet

  • David Scholten

  • Hans Dieter Nischalke

  • Sabina Janciauskiene

  • Mattias Mandorfer

  • Michael H. Trauner

  • Michael J. Way

  • Andrew McQuillin

  • Matthias C. Reichert

  • Marcin Krawczyk

  • Frank Lammert

  • Felix M. Braun

  • Witigo von Schoenfels

  • Sebastian Hinz

  • Greta Burmeister

  • Claus Hellerbrand

  • Andreas Teufel

  • Monika Ridinger

  • Norbert Wodarz

  • Michael Soyka

  • Marcella Rietschel

  • Thomas Weber

  • Silke Marhenke

  • Arndt Vogel

  • Holger Hinrichsen

  • Ali Canbay

  • Martin Schlattjan

  • Katharina Sosnowsky

  • Christoph Sarrazin

  • Johann von Felden

  • Pierre Deltenre

  • Bence Sipos

  • Clemens Schafmayer

  • Elmar Aigner

  • Christian Datz

  • FelixStickel

  • Marsha Y. Morgan

  • Jochen Hampe

  • Thomas Berg

  • Christian Trautwein

Medical Centers

  • Medical Clinic III, Gastroenterology, Metabolic diseases and Intensive Care, University Hospital RWTH Aachen, Aachen, Germany, Aachen, Germany

  • Coordinating center for alpha1‐antitrypsin deficiency‐related liver disease of the European Reference Network (ERN) “Rare Liver” and the European Association for the Study of the Liver (EASL) registry group “Alpha1‐Liver", Aachen, Germany

  • Medical Dept. 1, University Hospital Dresden, TU Dresden, Dresden, Germany

  • Rheumatology Unit, Department of Internal Medicine, University Hospital Leipzig, Leipzig, Germany

  • Internal Medicine I, University of Cologne, Cologne, Germany

  • Clinic for Pneumology, German Center for Lung Research (DZL), Medical University Hannover, Hannover, Germany

  • Gastroenterology&Hepatology, Medical University of Vienna, Vienna, Austria

  • Institute for Liver & Digestive Health, Division of Medicine, University College London, London, United Kingdom

  • Molecular Psychiatry Laboratory, Division of Psychiatry, University College London, London, United Kingdom

  • Department of Medicine II, Saarland University Hospital, Homburg, Germany

  • Laboratory of Metabolic Liver Diseases, Department of General, Transplant and Liver Surgery, Medical University of Warsaw, Warsaw, Poland

  • Department of General Pediatrics, University Hospital Schleswig-Holstein, Kiel, Germany

  • Department of Internal Medicine, University Hospital Regensburg, Germany, Regensburg, Germany

  • Department of Psychology, University of Konstanz, Konstanz, Germany

  • Department of Psychiatry and Psychotherapy, University of Regensburg, Regensburg, Germany

  • Psychiatry, Ludwig-Maximilians-University, Munich, Germany

  • Central institute of mental health, university of Heidelberg, Mannheim, Germany

  • Department of Clinical Pharmacology, University Bern, Berne, Switzerland

  • Clinic of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany

  • Department of Gastroenterology, University Hospital Kiel, Kiel, Germany

  • Clinic of Gastroenterology, Hepatology and Infectious Diseases, Otto-von-Guericke University Hospital, Magdeburg, Germany

  • Department of Gastroenterology and Hepatology, University of Duisburg-Essen, Essen, Germany

  • Department of Internal Medicine II, University Hospital, Frankfurt/Main, Frankfurt,

  • I. Department of Internal Medicine, University Hospital Hamburg-Eppendorf, Hamburg, Germany

  • Division of Gastroenterology & Hepatology, Centre Hospitalier Universitaire Vaudois/CHUV, Lausanne, Switzerland

  • Department of Gastroenterology, Hepatopancreatology and Digestive oncology, ULB Erasme Hospital, Brussels, Belgium

  • Institute for Neuropathology, University of Tuebingen, Tuebingen, Germany

  • Department III of Internal Medicine, University Hospital of Salzburg, Salzburg, Austria

  • Department of Internal Medicine, Hospital Oberndorf, Teaching Hospital of the Paracelsus Private University of Salzburg, Oberndorf, Austria

  • Division of Hematology, University Hospital Zurich, Zurich, Switzerland

Locations

  • Germany

  • Austria

  • United Kingdom

  • Poland

  • Switzerland

  • Belgium

Companies

  • N/A

Study Components

Therapeutic Area

  • Gastroenterology (GU)

Disease

  • Diabetes

  • Hepatic fibrosis

  • Cirrhosis

  • Nonalcoholic fatty liver disease

Biomarkers

  • Alpha-1 antitrypsin

  • Body mass index

Drug/Treatment

  • N/A

Outcome

  • N/A

Study Design

  • N/A

Phase

  • NA

Study Id's

  • N/A

Sponsors

  • N/A

Result

  • N/A

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