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EPCO-05 : LOSS OF THE H4 LYSINE METHYLTRANSFERASE KMT5B DRIVES INVASION / MIGRATION BY DEPLETING H3K27me3 AT LOCI OTHERWISE RETAINED IN H3K27M MUTANT DIPG CELLS

Researchers

Presenter

  • Ketty Kessler

Principal Investigators

  • Alan Mackay

  • Valeria Molinari

  • Haider Tari

  • Anna Burford

  • Andrea Sottoriva

  • Maria Vinci

  • Chris Jones

Medical Centers

  • Institute for Cancer Research, London, United Kingdom

  • Ospedale Pediatrico Bambino Gesu, Rome, Italy.

Locations

  • United Kingdom

  • Italy

Companies

  • N/A

Study Components

Therapeutic Area

  • Oncology (ONC)

Disease

  • Diffuse intrinsic pontine glioma

Biomarkers

  • Cyclin Dependent Kinase Inhibitor 2A

  • Trimethylation of lysine 27 on histone H3

Drug/Treatment

  • N/A

Outcome

  • N/A

Study Design

  • N/A

Phase

  • NA

Study Id's

  • N/A

Sponsors

  • N/A

Result

  • N/A

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