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1039 : Fragment-based drug discovery to identify small molecule allosteric inhibitors of SHP2

Researchers

Presenter

  • Philip J. Day

Principal Investigators

  • Juan Castro

  • Gianni Chessari

  • Thomas G. Davies

  • James E. Day

  • Satoshi Fukaya

  • Chris Hamlett

  • Keisha Hearn

  • Steve Hiscock

  • Rhian Holvey

  • Satoru Ito

  • Yasuo Kodama

  • Kenichi Matsuo

  • Yoko Nakatsuru

  • Nick Palmer

  • Amanda Price

  • Tadashi Shimamura

  • Jeffrey D.St. Denis

  • Nicola G. Wallis

  • Glyn Williams

  • Christopher N. Johnson

Medical Centers

  • Astex Pharmaceutical, Inc., Cambridge, United Kingdom.

  • Taiho Pharmaceutical Co., LTD., Tokyo, Japan

Locations

  • United Kingdom

  • Japan

Companies

  • N/A

Study Components

Therapeutic Area

  • Oncology (ONC)

Disease

  • Solid malignancies

Biomarkers

  • Mitogen-activated protein kinase

  • Cluster of differentiation 45

  • Protein Tyrosine Phosphatase, Non-Receptor Type 11

  • KRAS proto-oncogene, GTPase

Drug/Treatment

  • L-Tyrosine

Outcome

  • N/A

Study Design

  • N/A

Phase

  • NA

Study Id's

  • N/A

Sponsors

  • N/A

Result

  • N/A

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