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PD5-11 : Association of immune gene expression with outcome in the MARIANNE phase 3 clinical trial in HER2-positive metastatic breast cancer (MBC)

Researchers

Presenter

  • Edith A Perez

Principal Investigators

  • Sanne Lysbet de Haas

  • Carlos H Barrios

  • Wolfgang Eiermann

  • Masakazu Toi

  • Young-Hyuck Im

  • Pier Franco Conte

  • Miguel Martin

  • Tadeusz Pienkowski

  • Xavier B Pivot

  • Howard A Burris, III

  • Chiara Lambertini

  • Silke Hoersch

  • Monika Patre

  • Paul Anthony Ellis

Medical Centers

  • Mayo Clinic, Jacksonville, FL

  • F. Hoffmann-La Roche Ltd., Basel, Switzerland

  • Latin American Cooperative Oncology Group, Porto Alegre, Brazil

  • Interdisciplinary Oncology Center, Munich, Germany

  • Graduate School of Medicine Kyoto University, Kyoto, Japan

  • Ophthalmology, Samsung Medical Center, Seoul, Korea (the Democratic People's Republic of)

  • Department of Surgery, Oncology and Gastroenterology, University of Padua, Medical Oncology 2, Instituto Oncologico Veneto IRCCS, Padova, Italy

  • Instituto de Investigacion Sanitaria Gregorio Maranon, Universidad Complutense, Madrid, Spain

  • Postgraduate Medical Center, Warsaw, Poland

  • Paul Strauss Cancer Center, Strasbourg, France

  • Sarah Cannon Research Institute/Tennessee Oncology, PLLC, Nashville, TN

  • Guys Hospital and Sarah Cannon Research Institute, London, United Kingdom

Locations

  • United States

  • Switzerland

  • Brazil

  • Germany

  • Japan

  • Republic of South Korea

  • Italy

  • Spain

  • Poland

  • France

  • United Kingdom

Companies

  • F. Hoffmann-La Roche

Study Components

Therapeutic Area

  • Oncology (ONC)

Disease

  • Breast cancer

Biomarkers

  • Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

  • Programmed death-ligand 1

  • Cluster of differentiation 8A

  • Human epidermal growth factor receptor 2

Drug/Treatment

  • Trastuzumab

  • taxane

  • Trastuzumab emtansine

Outcome

  • N/A

Study Design

  • Randomized

Phase

  • III

Study Id's

  • NCT01120184

Sponsors

  • N/A

Result

  • N/A

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