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PB1361 : TOutcomes of Patients with Worsening Acquired Thrombotic Thrombocytopenic Purpura (TTP) Despite Daily Therapeutic Plasma Exchange (TPE) in the Phase 3 HERCULES Trial

Researchers

Presenter

  • M. Scully

Principal Investigators

  • J. de la Rubia

  • F. Peyvandi

  • S. Cataland

  • P. Coppo

  • J.A. Kremer Hovinga

  • P. Knoebl

  • K. Pavenski

  • F. Callewaert

  • J. Minkue Mi Edou

  • R. de Passos Sousa

Medical Centers

  • University College London Hospital, Cardiometabolic Programme, NIHR UCLH/UCL BRC, Department of Haematology, London, United Kingdom

  • Catholic University of Valencia, Hematology Department, Internal Medicine, School of Medicine and Dentistry, Valencia, Spain

  • Hospital Dr Peset, Valencia, Spain

  • Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico, Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Milano, Italy

  • Universit degli Studi di Milano, Department of Pathophysiology and Transplantation, Milan, Italy

  • The Ohio State University, Division of Hematology, Department of Internal Medicine, Columbus, United States

  • Saint-Antoine University Hospital, AP-HP, Department of Hematology, Reference Center for Thrombotic Microangiopathies (CNR-MAT), Paris, France

  • Inselspital, Bern University Hospital, Department of Hematology and Central Hematology Laboratory, Bern, Switzerland

  • Medical University of Vienna, Division of Hematology and Hemostasis, Department of Medicine 1, Vienna, Austria

  • St. Michael's Hospital, University of Toronto, Departments of Medicine and Laboratory Medicine & Pathobiology, Toronto, Canada

  • Sanofi, Diegem, Belgium

  • Sanofi, Zwijnaarde, Belgium

  • Sanofi, Lisbon, Portugal

Locations

  • United Kingdom

  • Spain

  • Italy

  • United States

  • France

  • Switzerland

  • Austria

  • Canada

  • Belgium

  • Portugal

Companies

  • N/A

Study Components

Therapeutic Area

  • Genetic Disorder

  • Blood/haematological Diseases

Disease

  • Thrombotic thrombocytopenic purpura

Biomarkers

  • Creatinine

  • Lactate dehydrogenase

  • ZFP36 Ring Finger Protein Like 1

Drug/Treatment

  • ALX-0081

Outcome

  • N/A

Study Design

  • Placebo Control

Phase

  • III

Study Id's

  • N/A

Sponsors

  • N/A

Result

  • N/A

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