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PB1506 : Identification of a Novel Molecular Variant in the PTGS1 Gene that Causes a Loss of a Glycan in the Catalytic Domain, Defects in Platelet Thromboxane A2 Synthesis, and Bleeding

Researchers

Presenter

  • V. Palma-Barqueros

Principal Investigators

  • M. Chan

  • M.E. de la Morena-Barrio

  • J.M. Bastida

  • N. Bohdan

  • E. Almarza

  • S. Suarez-Varela

  • I. Casas-Aviles

  • J. Padilla

  • A. Rodriguez-Alen

  • A. Marin-Quilez

  • N. Revilla

  • V. Vicente

  • J. Corral

  • M.L. Edin

  • D. Zelding

  • M.L. Lozano

  • T. Warner

  • J. Rivera

Medical Centers

  • Servicio de Hematología y Oncología Médica, Hospital Universitario Morales Meseguer, Centro Regional de Hemodonación, Universidad de Murcia, IMIB‐Arrixaca, CB15/00055‐CIBERER, Murcia, Spain

  • Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, Select State, United Kingdom

  • Servicio de Hematología y Oncología Médica, Hospital Universitario Morales Meseguer, Centro Regional de Hemodonación, Universidad de Murcia, IMIB‐Arrixaca, CB15/00055‐CIBERER, Murcia, Spain

  • Unidad de Trombosis y Hemostasia. Hospital Universitario de Salamanca‐IBSAL, Salamanca, Spain

  • Division of Hematopoietic Innovative Therapies, Centro de Investigaciones Energéticas, Medioambientales y Tecnológicas (CIEMAT), Madrid, Spain

  • Servicio de Hematología, Hospital San Pedro de Alcántara, Complejo Universitario de Cáceres, Caceres, Spain

  • Servicio de Hematología y Hemoterapia, Hospital Virgen de la Salud, Complejo Hospitalario de Toledo, Toledo, Spain

  • National Institutes of Health, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, United States

Locations

  • Spain

  • United Kingdom

  • United States

Companies

  • N/A

Study Components

Therapeutic Area

  • N/A

Disease

  • N/A

Biomarkers

  • Cyclic AMP-dependent protein kinase

  • Cyclooxygenase-1

Drug/Treatment

  • N/A

Outcome

  • N/A

Study Design

  • N/A

Phase

  • NA

Study Id's

  • N/A

Sponsors

  • N/A

Result

  • N/A

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