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BSH19‐PO‐124 : The BELIEVE Trial: Results of a Phase 3, Randomised, Double‐Blind, Placebo‐Controlled Study of Luspatercept in Adult β‐Thalassaemia Patients Who Require Regular Red Blood Cell (RBC) Transfusions

Researchers

Presenter

  • J. Porter

Principal Investigators

  • E. Drasar

  • Q.A. Hill

  • P. Telfer

  • V. Viprakasit

  • A. Taher

  • P. Georgiev

  • K.H.M. Kuo

  • T. Coates

  • E. Voskaridou

  • H.K. Liew

  • I. Pazgal-Kobrowski

  • G. Forni

  • S. Perrotta

  • A. Khelif

  • A. Lal

  • A. Kattamis

  • E. Vlachaki

  • R. Origa

  • Y. Aydinok

  • M. Bejaoui

  • P.J. Ho

  • L.P. Chew

  • P.C. Bee

  • S.M. Lim

  • M.-Y. Lu

  • A. Tantiworawit

  • P. Ganeva

  • L. Gercheva

  • E.J. Neufeld

  • A. Laadem

  • J.K. Shetty

  • J. Zou

  • D. Miteva

  • T. Zinger

  • P.G. Linde

  • M. Sherman

  • O. Hermine

  • A. Piga

  • M.D. Cappellini

Medical Centers

  • University College London Hospital

  • University CollegeLondon, UK

  • Department of Rheumatology, Whittington Hospital NHS Trust, London, UK

  • StJamess University Hospital, Leeds, UK

  • Barts Health NHS Trust, London, United Kingdom

  • Ramathibodi Hospital, Mahidol University, Bangkok, Thailand

  • Department of Pediatrics and Adolescent Medicine, American University of Beirut Medical Center, Beirut, Lebanon

  • St George University Hospital for Active Treatment

  • Medical University Plovdiv, Plovdiv, Bulgaria

  • Division of Medical Oncology and Hematology, Department of Medicine, University Health Network

  • Division of Medical Oncology, Department of Medicine, University of Toronto, Toronto, ON, Canada

  • Children's Center for Cancer and Blood Diseases, Children's Hospital Los Angeles, Los Angeles, CA

  • USC Keck School of Medicine, Los Angeles, United States

  • Thalassemia and Sickle Cell Center ,Laiko General Hospital,Athens,Grecia

  • Hospital Sultanah Bahiyah, Alor Setar, Kedah, Malaysia

  • Comprehensive Center of Thalassemia,Rabin Medical Center, Beilinson Hospital,Petah Tikva,Israel

  • Centro della Microcitemia, Anemie Congenite e Dismetabolismo del Ferro, Ospedale Galliera, Genova, Italy

  • Università della Campania,Luigi Vanvitelli,Caserta,Italy

  • Farhat Hached University Hospital, Sousse, Tunisia

  • University of California San Francisco Benioff Children's Hospital,Oakland,United States

  • First Department of Radiology, Aretaieion Hospital, National and Kapodistrian University of Athens, Athens, Greece

  • Adult Thalassemia Unit, Hippokration Hospital, Thessaloniki, Greece

  • University Hospital of Cagliari, Cagliari, Italy

  • Department of Pediatric Hematology, Ege University Hospital, Izmir, Turkey

  • National Center of Bone Marrow Transplant and Faculty of Medicine, University of Tunis El Manar, Tunis, Tunisia

  • Royal Prince Alfred Hospital and University of Sydney, New South Wales, Australia

  • Hospital Umum Sarawak, Kuching

  • University of Malaya Medical Centre,Kuala Lumpur,马来西亚

  • Sultanah Aminah Hospital Johor Bahru Johor Malaysia

  • National Taiwan University Hospital, Taipei, Taiwan (Republic of China)

  • Division of Rheumatology, Department of Internal Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand

  • University Specialized Hospital for Active Treatment in Oncology, Sofia

  • Univ. Hospital St. Marina, Varna, Bulgaria

  • St. Jude Children's Research Hospital, Memphis, TN

  • 1Celgene Corporation Summit NJ United States

  • Celgene Corporation, Boudry, Switzerland

  • Acceleron Pharma, Cambridge, MA, United States.

  • Necker Hospital

  • Curie Institute, Paris, France

  • Dept of Clinical and Biological Sciences, University of Turin, Turin, Italy

  • Fondazione IRCCS Ca' Granda Maggiore Hospital, University of Milan, Milan, Italy

Locations

  • United Kingdom

  • Thailand

  • Lebanon

  • Bulgaria

  • Canada

  • United States

  • Greece

  • Malaysia

  • Israel

  • Italy

  • Tunisia

  • Turkey

  • Australia

  • Switzerland

  • France

  • Republic of South Korea

Companies

  • Celgene Corporation

Study Components

Therapeutic Area

  • Blood/haematological Diseases

Disease

  • Transfusion‐dependent β‐thalassaemia

Biomarkers

  • Red Blood Cells

Drug/Treatment

  • luspatercept

Outcome

  • N/A

Study Design

  • Randomized

  • Placebo Control

  • Double Blind/Blinded

  • Controlled

Phase

  • III

Study Id's

  • NCT02604433

Sponsors

  • N/A

Result

  • N/A

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