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BSH2020‐PO‐145 : One‐year efficacy of ravulizumab (ALXN1210) in adult patients with paroxysmal nocturnal hemoglobinuria naive to complement inhibitors

Researchers

Presenter

  • H. Schrezenmeier

Principal Investigators

  • S. Gandhi

  • A. Kulasekararaj

  • L. Mitchell

  • F. Sicre de Fontbrune

  • T. Devos

  • S. Okamoto

  • R. Wells

  • S. Rottinghaus

  • P. Liu

  • S. Ortiz

  • L. Shafner

  • J. W. Lee

  • G. Soci

Medical Centers

  • Institute of Transfusion Medicine, University of Ulm, Germany ,

  • Institute for Clinical Transfusion Medicine and Immunogenetics Ulm German Red Cross Blood Service Baden-Wurttemberg, University Hospital Ulm, Ulm, Germany

  • Department of Haematological Medicine,King’s College Hospital, NIHR/Wellcome King’s Clinical Research Facility,London,United Kingdom

  • University Hospital Monklands,North Lanarkshire,United Kingdom

  • Centre de Référence Aplasie Médullaire, Service d'Hématologie Greffe,Assistance Publique des Hôpitaux de Paris, Hôpital Saint-Louis,Paris,France

  • Hematology,University Hospitals Leuven and Laboratory of Experimental Transplantation, Department of Microbiology and Immunology,KU Leuven,Belgium

  • Alexion Pharmaceuticals, Inc., Boston, United States

  • Department of Hematology, Seoul St. Mary's Hospital, The Catholic University of Korea, Seoul, South Korea,

  • Hematology Transplantation, Hôpital Saint‐Louis

  • Université de Paris, Institut National de la Santé et de la Recherche Médicale U976, Paris, France

Locations

  • Germany

  • United Kingdom

  • France

  • Belgium

  • Japan

  • Canada

  • United States

  • Republic of South Korea

Companies

  • N/A

Study Components

Therapeutic Area

  • Blood/haematological Diseases

Disease

  • Paroxysmal nocturnal hemoglobinuria

Biomarkers

  • Lactate dehydrogenase

Drug/Treatment

  • Eculizumab

  • ALXN-1210

Outcome

  • N/A

Study Design

  • Randomized

  • Controlled

Phase

  • III

Study Id's

  • NCT02946463

Sponsors

  • N/A

Result

  • N/A

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