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TPS5588 : A phase III randomized, placebo-controlled, double-blind study of niraparib plus abiraterone acetate and prednisone versus abiraterone acetate and prednisone in patients with metastatic prostate cancer (MAGNITUDE).

Researchers

Presenter

  • Kim N. Chi

Principal Investigators

  • Dana E. Rathkopf

  • Gerhardt Attard

  • Matthew Raymond Smith

  • Eleni Efstathiou

  • David Olmos

  • Eric Jay Small

  • Ji Youl Lee

  • Deborah S. Ricci

  • Jason S. Simon

  • Xin Zhao

  • Nishi Kothari

  • Shinta Cheng

  • Shahneen Kaur Sandhu

Medical Centers

  • Vancouver Prostate Centre, Vancouver, BC, Canada

  • Memorial Sloan Kettering Cancer Center, Port Washington, NY

  • The Institute of Cancer Research & The Royal Marsden, London, Spain

  • Massachusetts General Hospital Cancer Center, Boston, MA

  • Department of Genitourinary Medical Oncology, Division of Cancer Medicine, Houston, TX

  • Prostate Cancer Clinical Research Unit, Spanish National Cancer Research Centre (CNIO), Madrid, Spain

  • UCSF Helen Diller Family Comprehensive Cancer Center, San Francisco, CA

  • Seoul St. Mary's Hospital, The Catholic University of Korea, Seoul, South Korea,

  • Janssen Research and Development, LLC, Spring House, PA

  • Janssen Research & Development, LLC, Raritan, NJ

  • Janssen Research & Development, San Diego, CA

  • Janssen Research & Development, Los Angeles, CA

  • Peter MacCallum Cancer Centre, East Melbourne, Australia

Locations

  • Canada

  • United States

Companies

  • N/A

Study Components

Therapeutic Area

  • Oncology (ONC)

  • Nephrology

Disease

  • N/A

Biomarkers

  • N/A

Drug/Treatment

  • CB-7598

  • Prednisone

  • Niraparib

  • Androgen Tear

Outcome

  • N/A

Study Design

  • Randomized

  • Placebo Control

  • Pharmacokinetics

  • Double Blind/Blinded

  • Superiority

  • Multicenteric

  • Controlled

  • Cohort

Phase

  • NA

Study Id's

  • NCT03748641

Sponsors

  • N/A

Result

  • N/A

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