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: Bnip3 Displaces Uncoupling Protein3 (UCP3) from cytochrome C oxidase of respiration chain complex IV promoting maladaptive autophagy and necrotic cell death in doxorubicin cardiotoxicity

Researchers

Presenter

  • L.A. Kirshenbaum

Principal Investigators

  • V. Margulets

  • R. Dhingra

  • M. Guberman

  • B. Lieberman

Medical Centers

  • The Institute of Cardiovascular Sciences, St Boniface General Hospital Research Centre, Winnipeg, Canada

Locations

  • Canada

Companies

  • N/A

Study Components

Therapeutic Area

  • Cardiovascular (CVS)

Disease

  • N/A

Biomarkers

  • Nucleoside diphosphate kinase A

  • Proto-oncogene tyrosine-protein kinase ROS

  • Cyclooxygenase-1

  • Lactate dehydrogenase

Drug/Treatment

  • Doxorubicin

Outcome

  • N/A

Study Design

  • N/A

Phase

  • NA

Study Id's

  • N/A

Sponsors

  • N/A

Result

  • N/A

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