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: Interferon-gamma (IFN-γ) Neutralization with Emapalumab and Time to Response in Patients with Macrophage Activation Syndrome (MAS) Complicating Systemic Juvenile Idiopathic Arthritis (s-JIA) who failed High-Dose Glucocorticoids

Researchers

Presenter

  • Paul Brogan

Principal Investigators

  • Alexei A. Grom

  • Pierre Quartier

  • Rayfel Schneider

  • Jordi Anton

  • Claudia Bracaglia

  • Manuela Pardeo

  • Giulia Marucci

  • Emanuela Sacco

  • Despina Eleftheriou

  • Charalampia Papadopoulou

  • Philippe Jacqmin

  • maria ballabio

  • Cristina de Min

Medical Centers

  • Bambino Gesu Childrens Hospital, Rome, Italy

  • Great Ormond Street Hospital for Children NHS Foundation Trust, London, United Kingdom

  • Division of Nephrology, Cincinnati Childrens Hospital Medical Center, Cincinnati, OH

  • Necker Hospital, Paris, France

  • Hospital for Sick Children, Toronto, ON, Canada

  • Hospital Sant Joan de Deu de Barcelona, Barcelona, Spain

  • Division of Rheumatology, IRCCS Ospedale Pediatrico Bambino Gesù, Rome, Italy, Rome

  • Division of Rheumatology, IRCCS Ospedale Pediatrico Bambino Gesù, Rome, Italy, Rome

  • Division of Rheumatology, IRCCS Ospedale Pediatrico Bambino Gesù, Rome, Italy, Rome

  • UCL Institute of Child Health, and Great Ormond Street Hospital NHS Foundation Trust, Infection, Immunology, and Rheumatology section,, london, United Kingdom

  • UCL Institute of Child Health, and Great Ormond Street Hospital NHS Foundation Trust, Infection, Immunology, and Rheumatology section,, london, United Kingdom

  • MnS, Dinant, Belgium

  • Sobi AG, basel, Switzerland

Locations

  • Italy

  • United Kingdom

  • United States

  • France

  • Canada

  • Spain

  • Belgium

  • Switzerland

Companies

  • N/A

Study Components

Therapeutic Area

  • Autoimmune (AI)

Disease

  • N/A

Biomarkers

  • Alanine transaminase

  • Aspartate aminotransferase

  • C-X-C motif chemokine ligand 9

  • Interferon-gamma

  • Lactate dehydrogenase

Drug/Treatment

  • Interferon Gamma

  • Glucocorticoid

  • NI0501

  • Fibrinogen (IV)

  • Interferon

Outcome

  • N/A

Study Design

  • Open Label

  • Single Arm

  • Multinational

Phase

  • NA

Study Id's

  • N/A

Sponsors

  • N/A

Result

  • N/A

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