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WP262 : Therapeutically Targeting TNF?-S1P Signaling Restores Microvascular Reactivity after Experimental Subarachnoid Hemorrhage

Researchers

Presenter

  • Div of Neurosurgery

Principal Investigators

  • Darcy Lidington

  • Steffen-Sebastian Bolz

  • Anja Meissner

  • Jinglu Ai

  • Hoyee Wan

  • Sergei Nedospasov

  • Stefan Offermanns

  • Shinji Nagahiro

  • Robert Loch Macdonald

Medical Centers

  • Univ of Toronto at the Li Ka Shing Knowledge Inst at St. Michaels Hosp, Toronto Ctr for Microvascular Med, Toronto, ON, Canada

  • Univ of Toronto, Heart & Stroke / Richard Lewar Ctr of Excellence for Cardiovascular Res, Toronto, ON, Canada

  • Inst of Health Biosciences, Dept of Neurosurgery, The Univ of Tokushima Graduate Sch, Tokushima, Japan

  • Univ of Toronto, Dept of Physiology, Toronto, ON, Canada

  • Rescu, Li Ka Shing Knowledge Inst, St. Michael's Hosp

  • Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany.

  • The Univ of Tokushima, Keenan Res Ctr in Li Ka Shing Knowledge Inst of St Michael's Hosp and Inst of Health Biosciences, St Michael's Hosp, Toronto, ON, Canada

  • Univ of Toronto, Keenan Res Ctr in Li Ka Shing Knowledge Inst of St Michael's Hosp and Dept of Surgery, St Michael's Hosp, Toronto, ON, Canada

Locations

  • Canada

  • Japan

  • Germany

Companies

  • N/A

Study Components

Therapeutic Area

  • Cardiovascular (CVS)

Disease

  • Subarachnoid hemorrhage

  • Cystic Fibrosis

  • Vasospasm

  • Coronary Artery Disease

Biomarkers

  • Sphingosine-1-phosphate

  • Tumor necrosis factor

Drug/Treatment

  • Phenylephrine

  • Etanercept

  • CHS-0214

Outcome

  • N/A

Study Design

  • N/A

Phase

  • NA

Study Id's

  • N/A

Sponsors

  • N/A

Result

  • Interim

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