// App-Quantinova.ai

16631 : Genetic Deficiency of the Hydrogen Sulfide H2S Enzyme, Cystathionine Gamma-lyase (CSE) Results in eNOS Uncoupling and Exacerbated Myocardial Injury: Evidence for Cross Talk Between NO and H2S Signaling

Researchers

Presenter

  • Shashi Bushan

Principal Investigators

  • Kazushisa Kondo

  • Chad Nicholson

  • David Polhemus

  • John W Calvert

  • Tammy Dugas

  • Valeria Hebert

  • Rui Wang

  • David J Lefer

Medical Centers

  • Emory University School of Medicine, Atlanta, GA

  • LSU Health Sci Ctr, Shreveport, LA

  • Nagoya Univ, Showa-Ku, Japan

  • Lakehead Univ, Ontario, ON, Canada

Locations

  • United States

  • Canada

  • Japan

Companies

  • N/A

Study Components

Therapeutic Area

  • Cardiovascular (CVS)

Disease

  • Ischemia-reperfusion injury

  • Coronary Artery Disease

  • Myocardial injury

  • Congestive heart failure

Biomarkers

  • Endothelial cell nitric oxide synthase

  • Interferon

Drug/Treatment

  • Sapropterin

  • Nitric oxide

  • Cysteine Hydrochloride

  • folitixorin calcium

Outcome

  • N/A

Study Design

  • N/A

Phase

  • NA

Study Id's

  • N/A

Sponsors

  • N/A

Result

  • Interim

Copyright © 2026. QuantiNova All rights reserved