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16516 : Sustained LDL-C Lowering and Stable Hepatic Fat Levels in Patients With Homozygous Familial Hypercholesterolemia Treated With the Microsomal Triglyceride Transfer Protein Inhibitor, Lomitapide: Results of an Ongoing Long-Term Extension Study

Researchers

Presenter

  • Dirk J Blom

Principal Investigators

  • Maurizio R Averna

  • LeAnne T Bloedon

  • Daniel J Rader

  • Emma A Meagher

  • Hendrik Du T Theron

  • Cesare R Sirtori

  • Robert A Hegele

  • Prediman K Shah

  • Daniel Gaudet

  • Claudia Stefanutti

  • Giovanni B Vigna

Medical Centers

  • Univ of Montreal, Chicoutimi, QC, Canada

  • Universit di Roma 1, Roma, Italy

  • University of Pennsylvania, Philadelphia, PA

  • Ospedale Niguarda, Milano, Italy

  • Cedars-Sinai Health System, Los Angeles, CA

  • University of Cape Town, Cape Town, South Africa

  • University of Ferrara, Ferrara, Italy

  • Netcare Private Hosp, Bloemfontein, South Africa

  • Univ di Palermo, Palermo, PA

  • University of Western Ontario, London, ON, Canada

Locations

  • United States

  • Canada

  • Italy

  • South Africa

Companies

  • Aegerion Pharmaceuti

Study Components

Therapeutic Area

  • Cardiovascular (CVS)

Disease

  • Hypercholesterolemia, Familial, 1

  • Cardiac arrest

Biomarkers

  • Alanine transaminase

  • Apolipoprotein B

  • Nucleoside diphosphate kinase A

  • Cytochrome P450 Family 3 Subfamily A Member 4

  • Triglyceride Level

Drug/Treatment

  • Biaxin

  • Agomelatine

  • Lomitapide

Outcome

  • N/A

Study Design

  • open label

Phase

  • NA

Study Id's

  • N/A

Sponsors

  • N/A

Result

  • Interim

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