// App-Quantinova.ai

13767 : BRCA1 Reduces Oxidative Stress, Up-Regulates Nitric Oxide Production, and Attenuates Endothelial Cell Apoptosis: A Novel Target for Reduced Endothelial Dysfunction

Researchers

Presenter

  • Praphulla Shukla

Principal Investigators

  • Adrian Quan

  • Mohammed Al-Omran

  • Fina Lovren

  • Yi Pan

  • Christine Brezden-Masley

  • Alistair Ingram

  • William Stanford

  • Hwee Teoh

  • Subodh Verma

Medical Centers

  • St. Michael's Hosp, Toronto, ON, Canada

  • Sprott Ctr for Stem Cell Res, Ottawa, ON, Canada

  • McMaster University, Hamilton, ON, Canada

  • St. Michael's Hosp, Toronto, ON, Canada

  • King Saud University, Riyadh, Saudi Arabia

Locations

  • Canada

  • Saudi Arabia

Companies

  • N/A

Study Components

Therapeutic Area

  • Oncology (ONC)

Disease

  • Vasodilation dysfunction

  • Coronary Artery Disease

  • Ovarian cancer

  • Acute limb ischemia

  • Solid malignancies

Biomarkers

  • Proto-oncogene tyrosine-protein kinase ROS

  • E-selectin

  • Intercellular adhesion molecule 1

  • Tumor necrosis factor

  • Vascular cell adhesion molecule 1

  • Vascular endothelial growth factor A

Drug/Treatment

  • Nitric oxide

  • Doxorubicin

  • ICAM-1

Outcome

  • N/A

Study Design

  • N/A

Phase

  • NA

Study Id's

  • N/A

Sponsors

  • N/A

Result

  • Interim

Copyright © 2026. QuantiNova All rights reserved