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432 : MEK/ERK Inhibition Corrects the Defect in VLDL Assembly and Secretion in HepG2 Cells via Activation of Cell Death-Inducing DFFA-Like Effector B (Cide B), ApoCIII and Lipin-1

Researchers

Presenter

  • Wei Qiu

Principal Investigators

  • Jing Zhang

  • Huajin Wang

  • George M Carman

  • Meenakshi Sundaram

  • Zemin Yao

  • Nabil G Seidah

  • Khosrow Adeli

Medical Centers

  • Rutgers University, New Brunswick, NJ

  • Hospital for Sick Children, Toronto, ON, Canada

  • Univ of Ottawa, Ottawa, Canada

  • Clin Res Inst of Montreal, Montreal, Canada

Locations

  • United States

  • Canada

Companies

  • N/A

Study Components

Therapeutic Area

  • Cardiovascular (CVS)

  • Autoimmune (AI)

Disease

  • Giant cell arteritis

Biomarkers

  • Peripheral blood mononuclear cell

  • Cluster of Differentiation 25

  • Cluster of Differentiation 2AP

  • Cluster of differentiation 86

  • Extracellular signal-regulated kinase

  • Interleukin 1

  • Interleukin 17A

  • Lipin 1

  • Tumor necrosis factor

  • Type 1 T helper

Drug/Treatment

  • Glucocorticoid

  • Interleukin

  • SERP-1

Outcome

  • N/A

Study Design

  • N/A

Phase

  • NA

Study Id's

  • N/A

Sponsors

  • N/A

Result

  • Interim

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