// App-Quantinova.ai

16333 2014 AHA : PI3K? Has a Role in Myocardial Insulin Signaling and Recovery From Cre/Tamoxifen Cardiotoxicity, but is not Required for Normal Function in the Adult Mouse Heart

Researchers

Presenter

  • Pavel Zhabyeyev

Principal Investigators

  • Vaibhav B Patel

  • Ratnadeep Basu

  • Jessica DesAulniers

  • Allan G Murray

  • Zamaneh Kassiri

  • Bart Vanhaesebroeck

  • Gavin Y Oudit

Medical Centers

  • Bart's Cancer Institute, London, United Kingdom

  • Univ. of Alberta, Edmonton, Alberta, Canada.

Locations

  • Canada

  • United Kingdom

Companies

  • N/A

Study Components

Therapeutic Area

  • Oncology (ONC)

Disease

  • Systolic dysfunction

  • Cardiotoxicity

  • Solid malignancies

Biomarkers

  • Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

  • Extracellular signal-regulated kinase

  • Insulin

Drug/Treatment

  • Tamoxifen

  • Alpelisib

Outcome

  • N/A

Study Design

  • N/A

Phase

  • NA

Study Id's

  • N/A

Sponsors

  • N/A

Result

  • Interim

Copyright © 2026. QuantiNova All rights reserved