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15546 2014 AHA : Loss of Mitochondrial UCP3-Cytochrome c Oxidase Complexes Underlies Maladaptive Autophagy and Cardiac Failure in Anthracycline Cardiotoxicity

Researchers

Presenter

  • Victoria Margulets

Principal Investigators

  • Davindar Jassal

  • Gerald Dorn II

  • Lorrie A Kirshenbaum

Medical Centers

  • St. Boniface Res Ctr, Winnipeg, MB, Canada

  • Washington Univ, Washington, DC

Locations

  • United States

  • Canada

Companies

  • N/A

Study Components

Therapeutic Area

  • Oncology (ONC)

Disease

  • Mitochondrial Injury

  • Congestive heart failure

  • Cardiotoxicity

  • Solid malignancies

Biomarkers

  • Nucleoside diphosphate kinase A

  • Proto-oncogene tyrosine-protein kinase ROS

  • Lactate dehydrogenase

Drug/Treatment

  • Doxorubicin

Outcome

  • N/A

Study Design

  • adaptive

Phase

  • NA

Study Id's

  • N/A

Sponsors

  • N/A

Result

  • Interim

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