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11698 2014 AHA : Pulmonary Hypertension in S100A1 KO Mice is Associated With Endothelial Cell Dysfunction and Impaired eNOS Activation Dependent in Part on the Receptor for Advanced Glycation End-Products (RAGE)

Researchers

Presenter

  • Jean-Francois Desjardins

Principal Investigators

  • Wolfgang M Kuebler

  • Thomas G Parker

Medical Centers

  • St Michael's Hosp, Li Ka Shing Knowledge Inst, Rescu, Toronto, ON, Canada

Locations

  • Canada

Companies

  • N/A

Study Components

Therapeutic Area

  • Cardiovascular (CVS)

Disease

  • Vasodilation dysfunction

  • Pulmonary arterial hypertension

  • Hypertension

Biomarkers

  • Advanced Glycosylation End-Product Specific Receptor

  • Endothelial cell nitric oxide synthase

Drug/Treatment

  • Acetylcholine

  • Nitric oxide

  • Angiotensin II

Outcome

  • N/A

Study Design

  • N/A

Phase

  • NA

Study Id's

  • N/A

Sponsors

  • N/A

Result

  • Interim

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